Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity

This trial is comparing two types of spinal anesthesia (numbing medicine injected into the spine) for people undergoing above-the-knee leg amputation due to bone or soft tissue cancer. One approach uses fentanyl alone, and the other combines fentanyl with dexmedetomidine, to see which provides better pain control. **You may be eligible if...** - You are 18–60 years old - You are scheduled for above-knee leg amputation due to a sarcoma (bone or soft tissue cancer) - Your height is between 150–185 cm and your BMI is 18–35 - You are classified as ASA II or III (moderate underlying health conditions) **You may NOT be eligible if...** - You have a known allergy to any of the study medications - You have a heart rhythm problem, heart block, or are on certain heart medications (beta-blockers, calcium channel blockers, ACE inhibitors) - You have a condition that makes spinal anesthesia unsafe - You are pregnant or breastfeeding - You have a psychiatric illness or chronic pain condition Talk to your doctor to see if this trial is right for you.