RecruitingNot ApplicableNCT06579664

Intermittent Theta Burst Stimulation on Cognitive Impairment of Cerebral Small Vessel Disease

Sponsor

Beijing Tiantan Hospital

Enrollment

58 participants

Start Date

Mar 24, 2025

Study Type

INTERVENTIONAL

Conditions

Cognitive Impairment Cerebral Small Vessel Diseases

Summary

The cerebral small vessel diseases (CVSD) can cause severe and lasting damage to cognition function while the current available treatment of vascular cognitive impairment (VCI) is limited. The purpose of this study is to explore the feasibility, safety, and efficacy of intermittent Theta Burst Stimulation (iTBS) on cognitive impairment of cerebral small vessel disease.

Eligibility

Min Age: 45 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called iTBS and a medical device called sham iTBS for people with cerebral small vessel diseases and cognitive impairment. The study is currently recruiting participants at 1 location. People eligible for this study include aged 45 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEiTBS

Participants in active group will receive iTBS stimulation in 50-Hz triplets at 5 Hz for 600 seconds per session (2 seconds on and 8 seconds off) at 90% of their resting motor threshold to the left dorsolateral prefrontal cortex (DLPFC).Each intervention day includes 4 sessions (1800 pulses/session) of stimulation delivering a total of 7200 active pulses. This treatment protocol will be conducted 15 consecutive days.

DEVICEsham iTBS

Participants in the sham group will receive sham iTBS stimulation, which will use the same stimulation parameters, dosage, and duration as the active group, but will employ a sham coil. The sham coil is identical in appearance to the real stimulus coil and simulate the sound of a real stimulus, but do not produce a real stimulus.