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RecruitingNCT06580418

Evaluation of an Anti-TREM-1 Treatment on an ex Vivo Human Intestinal Model

Sponsor

Inotrem

Enrollment

40 participants

Start Date

Jan 31, 2023

Study Type

OBSERVATIONAL

Conditions

Inflammatory Bowel Diseases

Summary

TIME is an observational study performed on UC and CD patients under endoscopic surveillance for monitoring the clinical activity of their disease. The main objective of the study is to confirm the therapeutic potential of TREM-1 in inflammatory bowel disease.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria4

  • Patients between 18 and 60 years
  • Signed informed consent
  • Ulcerative colitis (UC) patients with active disease
  • Crohn's disease (CD) patients with active disease

Exclusion Criteria2

  • UC or CD patients in remission
  • Patients between 18 and 60 years without informed consent

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Interventions

OTHERAdditional biopsies and blood samples

During the endoscopic procedure planned for IBD patients following standard clinical practice, the endoscopist will decide the number and location of additional biopsy samples (up to 8) collected for the study. Participation in this study also requires the removal of three additional blood samples.

Locations(1)

IRCCS San Raffaele

Milan, Italy

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NCT06580418

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