RecruitingPhase 4NCT06582680
Aging, Beta Blockers, and Thermoregulatory Responses
Sponsor
University of Texas Southwestern Medical Center
Enrollment
22 participants
Start Date
Oct 4, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
Eligibility
Min Age: 65 Years
Inclusion Criteria5
- Healthy and free of any significant medical problems
- Normal resting electrocardiogram
- + years of age
- Controlled cholesterol of less than 200 mg/dl
- Controlled blood pressure of less than 140/90 mmHg
Exclusion Criteria5
- Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
- Serious abnormalities detected on routine screening
- Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating
- Current smokers, as well as individuals who regularly smoked within the past 3 years
- body mass index ≥31 kg/m2
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Interventions
OTHERAmbient Heat
Subjects will spend 3-hours in a heat chamber at 41°C and 40% humidity.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06582680
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