RecruitingNot ApplicableNCT06587165

Quantifying New Heart Muscle Cells

A Pilot Study for Quantifying New Heart Muscle Cells

Sponsor

Weill Medical College of Cornell University

Enrollment

30 participants

Start Date

Jul 23, 2015

Study Type

INTERVENTIONAL

Conditions

Heart Failure Tetralogy of Fallot With Pulmonary Stenosis

Summary

Regenerative therapies could provide new ways of treating heart failure. Unlike many organs in the human body, such as the skin and the GI tract, the ability to regenerate heart muscle decreases after birth, but the precise timing of this decrease and how this decrease is altered in heart disease are uncertain. The investigators will use an innovative approach to quantify cellular heart regeneration in pediatric patients, an appropriate population for determining this decline as well as the potential for reactivating heart muscle regeneration. The study has now been registered on ClinicalTrials.gov, despite its initiation on July 23, 2015, as registration was not mandated at the original study site, the University of Pittsburgh Medical Center. However, following the transfer of the study to Weill Cornell Medicine, adherence to institutional requirements necessitated its registration on ClinicalTrials.gov.

Eligibility

Min Age: 30 DaysMax Age: 1 Year

Plain Language Summary

Simplified for easier understanding

This study is examining how new heart muscle cells form in infants with congenital heart disease who are undergoing heart surgery. Researchers will analyze small pieces of heart tissue removed during necessary surgical procedures to better understand how the heart grows and repairs itself in early life. **You may be eligible if...** - The patient is between 30 days and 1 year of age - They are scheduled for elective heart surgery for a condition that typically requires removal of a small amount of heart muscle (such as Tetralogy of Fallot with pulmonary stenosis) - The surgery is part of their standard care (not done solely for research purposes) **You may NOT be eligible if...** - The patient is older than 1 year - The surgical approach does not require myocardial (heart muscle) tissue removal - Parents or guardians are unable or unwilling to provide informed consent - The patient has a condition that makes tissue analysis impossible Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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