RecruitingNCT06587854

a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure

a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart


Sponsor

University Medical Center Groningen

Enrollment

270 participants

Start Date

May 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients. The main question\[s\] it aims to answer \[is/are\]: * Primary objective: to study the prevalence of distinct congestion phenotypes * Other objectives (including): * Response to therapy as assessed by * Natriuresis after 24 hours * Rehospitalization and/or deats after 6 months * Length of hospital stay * Congestion at discharge * Changes in filling pressures over time * Relationship between liver stiffness, as assessed with Fibroscan and congestion * Substudy: glycosaminoglycan netword and endothial glycocalyx Participants will undergo several extra study related measurements: * Assessment of filling pressures with ultrasound * Ultrasound investigation of the lungs and kidneys * Fibroscan of the liver * Sidestream darkfield imaging sublingual * As part of substudy GLYCO-AHF: skin biopsy to determine glycocalyx, as well as salt and water content. * As part of substudy PREACH-AHF: the effects of peripheral venous congestion and endothelial dysfunction on a large screen of plasma proteins


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is observing patients admitted to hospital with acute heart failure — a condition where the heart suddenly cannot pump enough blood, causing fluid to build up in the body. Researchers want to better understand different patterns of fluid overload to improve how it is diagnosed and treated. **You may be eligible if...** - You are 18 or older - You were admitted to hospital primarily because of acute heart failure with signs of fluid buildup (such as shortness of breath or swelling) - You need intravenous (IV) diuretics (water pills given through a drip) to remove excess fluid **You may NOT be eligible if...** - You have severe kidney disease requiring dialysis or special filtration treatment - You have already participated in this study before - Your shortness of breath or swelling is mainly caused by a non-heart problem - You are unable to follow instructions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

UMCG

Groningen, Netherlands

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NCT06587854


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