RecruitingPhase 2Phase 3NCT06590324

A Study of Apabetalone in Subjects With Long -COVID

A Phase II, Multi-centre Open Label Study to Assess the Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditions) and Type 2 Diabetes Mellitus (T2DM)


Sponsor

Resverlogix Corp

Enrollment

200 participants

Start Date

Apr 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open label, multicentre, phase II clinical trial that aims to assess the efficacy and safety of oral Apabetalone with background dapagliflozin for up to 12 weeks in T2DM patients with a history of probable or confirmed SARS-CoV-2 infection, with symptoms within 3 months from the onset of COVID-19 that last for at least 2 months and cannot be explained by an alternative diagnosis.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a drug called apabetalone, combined with a diabetes medication called dapagliflozin, can help reduce the ongoing symptoms of Long COVID in people who also have Type 2 diabetes. Long COVID includes persistent fatigue, brain fog, and other symptoms that continue for months after a COVID-19 infection. **You may be eligible if...** - You are 18 or older and have Type 2 diabetes - You are currently taking or willing to start taking dapagliflozin - You had Long COVID symptoms starting within 3 months of a COVID-19 infection, and those symptoms have lasted at least 2 months - Your Long COVID is significantly impacting your life (scored above 30 on the Long Covid Impact Tool) - You currently test negative for COVID-19 **You may NOT be eligible if...** - You have severe kidney disease (eGFR below 25) - You have severe heart failure (NYHA Class IV) - You have liver cirrhosis, active hepatitis, or significant liver abnormalities - You have HIV, Hepatitis B, or Hepatitis C - You received a COVID-19 vaccine or booster within the last 30 days - You are pregnant, planning pregnancy, or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGApabetalone

100-mg capsule, twice daily oral administration with meals


Locations(3)

The Speciality Hospital

Amman, Jordan

MNGHA- King Abdulaziz Hospital

Al Mubarraz, Saudi Arabia

Al Kuwait Hospital

Dubai, Dubai, United Arab Emirates

View Full Details on ClinicalTrials.gov

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NCT06590324


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