Cardiac Radioablation for VT
A Phase I/II Study of Cardiac Radioablation for Refractory Ventricular Tachycardia
Corewell Health East
24 participants
Sep 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .
Eligibility
Inclusion Criteria10
- Participants must be 18 years or older.
- Automatic implanted cardiac defibrillator present.
- VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm.
- Ejection fraction ≥20%.
- At least one previous cardiac ablation for VT.
- VT refractory despite antiarrhythmic medications.
- Likely to live for 12 months in the absence of VT.
- AICD in a position in the chest RT to be given without direct radiation.
- Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT.
- The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice.
Exclusion Criteria4
- Class IV heart failure
- Abandoned leads.
- Prior radiation therapy to the chest or upper abdomen.
- Interstitial lung disease.
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Interventions
Stereotactic body radiation therapy, which delivers precise, high-dose radiation non-invasively to generate thermal scarring to myocardial targets causing VT
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06593418