RecruitingNCT06595212

Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach

Genetics and Environment iNtersection In the Amyotrophic Lateral Sclerosis - FrontoTemporal Dementia Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach

Sponsor

Azienda Ospedaliero-Universitaria di Modena

Enrollment

45 participants

Start Date

Jan 29, 2024

Study Type

OBSERVATIONAL

Conditions

ALS FTD

Summary

The goal of this study is to learn from discordant twins affected by Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia the contribution of genetic background versus environmental exposure. The main questions it aims to answer is: * How far does the genetic background explain the onset of ALS/FTD in discordant twins? * Which environmental factors and events occurring in post-fetal life influence the onset or progression of this neurodegenerative condition? Participants with ALS and/or FTD with a monozygotic or dizygotic twin willing to contribute to this research will be followed up for two years by specialized Motor Neuron Disorders centers in Italy, donating biological specimen for -omic sciences analysis, and checking out if prodromal signs/symptoms of these two conditions will develop during time.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting genetic, biological, and clinical data from identical and non-identical twin pairs in Italy — where at least one twin has ALS (amyotrophic lateral sclerosis) or frontotemporal dementia (FTD) — to better understand how genes and environment together contribute to these diseases. **You may be eligible if...** - You are over 18 years old - You are a twin (identical or non-identical) and both you and your twin are willing to participate - At least one twin has been diagnosed with ALS or frontotemporal dementia (FTD) - Both twins are able to give informed consent - Both twins are able to provide biological samples (blood, saliva, etc.) at a minimum during the first visit **You may NOT be eligible if...** - Either twin is unwilling to complete baseline assessments or provide biological samples - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERmultiomic profile to assess genetic and environmental risk factiors

Genomic, epigenetic, proteomic, microbiome, immunology, biomarker, metabolite, pesticide, metal, and metalloid investigations will be conducted. The twins will be followed longitudinally from a clinical perspective, with biological sample collections to assess discordance and identify early disease signatures in unaffected individuals.