FTD Clinical Trials

21 recruitingLast updated: June 18, 2026

There are 21 actively recruiting ftd clinical trials across 14 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1. Top locations include Toronto, Ontario, Canada, Montreal, Quebec, Canada, Philadelphia, Pennsylvania, United States. Updated daily from ClinicalTrials.gov.


FTD Trials at a Glance

21 actively recruiting trials for ftd are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Toronto, Montreal, and Philadelphia. Lead sponsors running ftd studies include ALS Therapy Development Institute, Assistance Publique - Hôpitaux de Paris, and AC Immune SA.

Browse ftd trials by phase

Treatments under study

About FTD Clinical Trials

Looking for clinical trials for FTD? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new FTD trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about FTD clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting
Not Applicable

Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment

FTDAD - Alzheimer's DiseaseAD-MCI+1 more
Tianjin Huanhu Hospital60 enrolled1 locationNCT07643363
Recruiting
Not Applicable

Effects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) Patients

ALS (Amyotrophic Lateral Sclerosis)ALSFTDFrontal Temporal Dementia (FTD)
Centre hospitalier de l'Université de Montréal (CHUM)150 enrolled1 locationNCT06051123
Recruiting
Not Applicable

A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia

DementiaAlzheimer DiseaseAlzheimer Disease, Early Onset+3 more
University of Campania Luigi Vanvitelli50 enrolled1 locationNCT06668610
Recruiting
Phase 1Phase 2

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)

Frontotemporal DementiaFTDDementia, Frontotemporal+1 more
AviadoBio Ltd18 enrolled19 locationsNCT06064890
Recruiting
Not Applicable

Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders

PSP - Progressive Supranuclear PalsyAlzheimer Dementia (AD)MSA - Multiple System Atrophy+7 more
Universitaire Ziekenhuizen KU Leuven300 enrolled1 locationNCT07509125
Recruiting
Not Applicable

Transcranial Alternating Current Stimulation in Frontotemporal Dementia

Frontotemporal Dementia (FTD)Transcranial Alternating Current Stimulation
IRCCS Centro San Giovanni di Dio Fatebenefratelli30 enrolled1 locationNCT07505784
Recruiting

Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches

FTDALS (Amyotrophic Lateral Sclerosis)Frontotemporal Dementia (FTD)+3 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta230 enrolled4 locationsNCT06856850
Recruiting
Not Applicable

Social-cognitive Functioning: Validation of a New Neuropsychological Test

Frontotemporal Degeneration(FTD)Alzheimer's Disease(AD)Lewy Body Dementia (LBD)
Assistance Publique - Hôpitaux de Paris120 enrolled1 locationNCT05558709
Recruiting
Phase 2

Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia

fronto-temporal dementiaFrontotemporal DementiaFrontotemporal Degeneration+3 more
Johns Hopkins University50 enrolled1 locationNCT06604520
Recruiting

UPenn Observational Research Repository on Neurodegenerative Disease

Corticobasal Syndrome(CBS)Progressive Supranuclear Palsy (PSP)Primary Progressive Aphasia(PPA)+6 more
University of Pennsylvania1,000 enrolled1 locationNCT04715399
Recruiting

Comprehensive Assessment of Neurodegeneration and Dementia

DementiaMild Cognitive Impairment (MCI)Subjective Cognitive Impairment+7 more
McGill University1,573 enrolled19 locationsNCT03402919
Recruiting
Phase 1Phase 2

A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes

Frontotemporal DementiaFTDDementia, Frontotemporal+2 more
Passage Bio, Inc.30 enrolled10 locationsNCT04747431
Recruiting
Not Applicable

Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration

PSPFTDrTMS+5 more
Università degli Studi di Brescia120 enrolled1 locationNCT07316413
Recruiting

Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases

Alzheimer DiseaseParkinson DiseaseFTD+3 more
Ospedale Policlinico San Martino1,200 enrolled1 locationNCT07235111
Recruiting
Not Applicable

Neurofilament Light Chains and Cognitive Impairment in Chronic Psychiatric Disease

Alzheimer DiseaseSchizophreniaBipolar Disorder+1 more
Hôpital le Vinatier120 enrolled2 locationsNCT04946916
Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Amyotrophic Lateral SclerosisCorticobasal Degeneration (CBD)Progressive Supranuclear Palsy (PSP)+11 more
Mayo Clinic2,100 enrolled27 locationsNCT04363684
Recruiting
Phase 2

Nabilone for Agitation in Frontotemporal Dementia

Frontotemporal DementiaPrimary Progressive AphasiaFTD+3 more
Simon Ducharme, MD45 enrolled7 locationsNCT05742698
Recruiting
Early Phase 1

[18F]ACI-19626 PET in TDP-43 Proteinopathies

Amyotrophic Lateral Sclerosis(ALS)Alzheimer's Disease(AD)Frontotemporal Dementia (FTD)+2 more
AC Immune SA45 enrolled1 locationNCT06891716
Recruiting

Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders

Parkinson DiseaseAmyotrophic Lateral Sclerosis(ALS)Alzheimer&Amp;#39;s Disease (AD)+1 more
Neuromed IRCCS110 enrolled1 locationNCT06803784
Recruiting

ALS Research Collaborative

Amyotrophic Lateral SclerosisMotor Neuron DiseaseALS (Amyotrophic Lateral Sclerosis)+2 more
ALS Therapy Development Institute2,000 enrolled1 locationNCT06885918