Exploratory Research on Constructing a Computational Biological Model Based on NGS for MRD After Breast Cancer Surgery

This study is building a blood-based test to detect leftover cancer cells (called minimal residual disease, or MRD) after breast cancer surgery, using advanced DNA sequencing. The goal is to identify who might relapse before symptoms appear. **You may be eligible if...** - You are 18 or older - You have been confirmed with primary breast cancer by biopsy - You are planning to have breast cancer surgery - You will receive treatment before or after surgery - You are able to attend follow-up visits over 3 years - You have a life expectancy of at least 5 years **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have serious mental illness or substance abuse issues - You have had another type of cancer (not breast) in the past 5 years - There is suspicion of cancer spread to distant parts of the body - You have received a blood transfusion in the past 30 days - You carry a known harmful genetic mutation Talk to your doctor to see if this trial is right for you.