Postoperative Adjuvant Immunotherapy Combined with Radiotherapy Versus Surgery Alone in Locally Advanced UTUC

This study is testing whether adding immunotherapy and radiation therapy after surgery can improve outcomes for patients with locally advanced upper urinary tract cancer (cancer in the kidney pelvis or ureter) compared to surgery alone. **You may be eligible if...** - You have had surgery (nephroureterectomy) to remove your kidney and ureter due to cancer - Your cancer was confirmed to be advanced (pT3-4 or involving lymph nodes) - You have kidney function issues or medical reasons preventing chemotherapy - You are between 18 and 80 years old - You are in good functional health (KPS above 70) **You may NOT be eligible if...** - Your cancer had already spread to distant organs at the time of surgery - The surgery did not remove all visible cancer - You have had prior pelvic or abdominal radiation, inflammatory bowel disease, or prior systemic chemotherapy - You are pregnant or breastfeeding - You have had another cancer in the past 5 years (with exceptions) - You have lost more than 10% of your body weight in the last 6 months Talk to your doctor to see if this trial is right for you.