Advanced Urothelial Carcinoma Clinical Trials

11 recruiting

Advanced Urothelial Carcinoma Trials at a Glance

17 actively recruiting trials for advanced urothelial carcinoma are listed on ClinicalTrialsFinder across 6 cities in 3 countries. The largest study group is Phase 2 with 10 trials, with the heaviest enrollment activity in Chicago, Guangzhou, and Jacksonville. Lead sponsors running advanced urothelial carcinoma studies include Mabwell (Shanghai) Bioscience Co., Ltd., Mayo Clinic, and Shanghai Hengrui Pharmaceutical Co., Ltd..

Browse advanced urothelial carcinoma trials by phase

Treatments under study

About Advanced Urothelial Carcinoma Clinical Trials

Looking for clinical trials for Advanced Urothelial Carcinoma? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Advanced Urothelial Carcinoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Advanced Urothelial Carcinoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Phase 2

Phase II Study of Trastuzumab Rezetecan or in Combination With Adebrelimab in HER2-Expressing Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC)

Urothelial CarcinomaAdvanced Urothelial CarcinomaUrothelial Carcinoma Recurrent
Sun Yat-sen University96 enrolled6 locationsNCT07241793
Recruiting
Phase 3

A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

Locally Advanced Urothelial CarcinomaMetastatic Urothelial CarcinomaUnresectable Urothelial Carcinoma
National Cancer Institute (NCI)320 enrolled129 locationsNCT06524544
Recruiting
Phase 1

Cabozantinib in Combination With Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Cancer

Locally Advanced Urothelial CarcinomaMetastatic Urothelial CarcinomaUnresectable Urothelial Carcinoma+1 more
Emory University32 enrolled1 locationNCT04878029
Recruiting
Phase 1

A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma

Advanced Urothelial CarcinomaOral Drug AdministrationOpen Label
Flare Therapeutics Inc.120 enrolled12 locationsNCT05929235
Recruiting
Phase 1

Dual-Target Nectin-4/HER2 CAR-NK Cells in Advanced Urothelial Carcinoma

Urothelial CarcinomaLocally Advanced Urothelial CarcinomaMetastatic Urothelial Carcinoma+2 more
Beijing Biotech42 enrolled1 locationNCT07492628
Recruiting
Phase 1Phase 2

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast Carcinoma+97 more
Mayo Clinic132 enrolled1 locationNCT05269381
Recruiting
Phase 2

Pembrolizumab Maintenance After Enfortumab Vedotin (EV)/Pembro Induction in Front-Line Metastatic Urothelial Carcinoma

Metastatic Urothelial CarcinomaUnresectable Urothelial CarcinomaAdvanced Urothelial Carcinoma
Fox Chase Cancer Center97 enrolled1 locationNCT07221942
Recruiting
Phase 2

Consolidative Local Therapy (CLT) in Oligo-metastatic Urothelial Carcinoma

Locally Advanced Urothelial CarcinomaOligo-metastaic Urothelial Carcinoma
Yale University32 enrolled1 locationNCT07048457
Recruiting
Phase 2

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

Urothelial CarcinomaEsophageal CarcinomaHepatocellular Carcinoma+28 more
Mayo Clinic50 enrolled1 locationNCT06265285
Recruiting
Phase 3

A Phase III Study of SHR-A2102 Versus Investigator-selected Therapy in Advanced Urothelial Carcinoma

Advanced Urothelial Carcinoma
Shanghai Hengrui Pharmaceutical Co., Ltd.402 enrolled1 locationNCT06738251
Recruiting
Phase 1Phase 2

Clofarabine Therapy in Locally Advanced or Metastatic Urothelial Carcinoma

Advanced Urothelial CarcinomaMetastatic Urothelial Cancer
Ekaterina Laukhtina50 enrolled1 locationNCT07034053
Recruiting
Phase 3

A Study to Evaluate 9MW2821 Versus Chemotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Urothelial Cancer

Advanced Urothelial Carcinoma
Mabwell (Shanghai) Bioscience Co., Ltd.432 enrolled1 locationNCT06196736
Recruiting
Phase 2

Probiotics in Advanced Urothelial Carcinoma

ImmunotherapyAdvanced Urothelial CarcinomaProbiotics
Sun Yat-sen University222 enrolled3 locationsNCT06904573
Recruiting
Phase 1Phase 2

A Trial of SHR-A2102 With Antitumor Therapy in Advanced Urothelial Carcinoma

Advanced Urothelial Carcinoma
Shanghai Hengrui Pharmaceutical Co., Ltd.90 enrolled1 locationNCT06639347
Recruiting

Postoperative Adjuvant Immunotherapy Combined with Radiotherapy Versus Surgery Alone in Locally Advanced UTUC

Ureter CancerAdvanced Urothelial CarcinomaRenal Pelvic Carcinoma
Peking University First Hospital60 enrolled2 locationsNCT06598761
Recruiting
Phase 1Phase 2

9MW2821 Combined With Toripalimab Injection in Subjects With Local Advanced or Metastatic Urothelial Cancer

Advanced Urothelial Carcinoma
Mabwell (Shanghai) Bioscience Co., Ltd.100 enrolled1 locationNCT06079112
Recruiting
Phase 2

CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8Metastatic Gastroesophageal Junction Adenocarcinoma+30 more
Northwestern University94 enrolled1 locationNCT05733000