RecruitingNCT06599047

Regional Adipose Tissue Characteristics in Type II Diabetes

Sponsor

Concordia University, Montreal

Enrollment

140 participants

Start Date

May 1, 2016

Study Type

OBSERVATIONAL

Conditions

Obesity and Type 2 Diabetes Bariatric Patients Undergoing Bariatric Surgery Adipose Tissue Dysfunction Type 2 Diabetes Mellitus Bariatric Surgery Adipose Tissue Inflammation

Summary

Fat tissue in different parts of the body has different characteristics. Several studies have associated abdominal fat to an increased risk for multiple metabolic diseases, such as type 2 diabetes and cardiovascular disease, compared with fat located under the skin at the hips and thighs. However, the investigators do not know how the abdominal fat causes or contributes to the development of these diseases or how the development of these disease may in turn cause or contribute to changes in the fat tissue. The general objective of this study is to understand these mechanisms. To investigate these questions, the study will recruit 140 participants, both men and women aged 18-65 years. The participants will be divided into three groups: 40 people with obesity, 40 with diabetes, and 60 lean individuals. Participants will be recruited from patients at the CIUSSS du Nord-de-l'Île-de Montréal - Hôpital du Sacré-Coeur de Montréal who are awaiting bariatric or general abdominal surgery, as well as from the general population in the Montreal area.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the characteristics of fat tissue in different regions of the body (such as around the organs versus under the skin) in people with type 2 diabetes compared to people without diabetes, to better understand how fat distribution affects metabolic health. **You may be eligible if...** - You are a man or woman between 18 and 65 years old (pre- or post-menopausal) - You are scheduled to have bariatric surgery (if you have obesity) OR general abdominal surgery (if you are normal weight) - If you have obesity, your BMI is 30 kg/m2 or above - Your weight has been stable for at least 2 months **You may NOT be eligible if...** - You are a smoker - You have significant kidney impairment - You have uncontrolled thyroid disease - You have other medical conditions beyond diabetes (exceptions: controlled hypertension, controlled thyroid disease, or controlled cholesterol on stable medications) - You take medications that could affect study outcomes (exceptions include metformin, DPP-4 inhibitors, and certain blood pressure or cholesterol medications on stable doses) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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