Study of Tiprogrel in the Treatment of High-risk Patients with Acute Ischemic Cerebrovascular Events (THRIVE).
A Phase 2, Randomised, Double-blind, Positive-controlled, Multicentre Study of Tiprogrel in the Treatment of Patients with Acute Minor Ischaemic Stroke or High-risk Transient Ischaemic Attack.
Tianjin Institute of Pharmaceutical Research Co., Ltd
600 participants
Feb 21, 2025
INTERVENTIONAL
Conditions
Summary
This study is designed to evaluate efficacy and safety of tiprogrel in the treatment of patients with acute ischemic cerebrovascular events.
Eligibility
Inclusion Criteria5
- Age ≥ 40 years
- Acute Minor Ischaemic Stroke：AIS is defined as acute onset of neurological deficit attributed to focal brain ischaemia, NIHSS ≤5, and either of the following imaging characteristics:
- Acute single infarction with ≥50% stenosis of a major intracranial or extracranial artery.
- Acute multiple infarctions attributed to large-artery atherosclerosis, including non-stenotic vulnerable plaques.
- TIA with high risk of stroke: ABCD2 score ≥ 6 at the time of randomization, and the following imaging characteristic:
Exclusion Criteria25
- Bleeding or other pathological brain disorders including malformation, tumor, abscess or other major non-ischemic brain disease on baseline head CT or MRI
- Isolated or pure sensory symptoms, isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI.
- Preceding mRS> 2
- Contraindication to anti-platelet therapy
- Clear indication for anticoagulation
- Two or more antiplatelet drugs have been used continuously for ≥3 days before enrollment.
- Used heparin or oral anticoagulant drugs within 10 days before enrollment
- Undergone intravenous or arterial thrombolysis and mechanical thrombectomy within 24 hours before enrollment
- History of intracranial hemorrhage or amyloid angiopathy
- History of aneurysm
- Diagnosis or suspicious diagnosis of acute coronary syndrome
- History of asthma
- High-risk for bradyarrhythmia
- Anticipated requirement for long-term (>5 days) non-steroidal anti-inflammatory drugs or NSAIDs within the 8th day of randomization
- History of gastrointestinal bleeding within 3 months before enrollment or major surgery within 30 days
- Iatrogenic causes of minor stroke or TIA
- Planned or likely revascularization within the next 3 months, scheduled for surgery or interventional treatment requiring study drug cessation
- Severe non-cardiovascular comorbidity with life expectancy < 3 months
- Women of childbearing age who have not taken effective contraceptive measures and have a positive pregnancy test record, as well as women who are pregnant or breastfeeding
- Currently receiving an experimental drug or device
- Participation in another clinical study with an experimental product during the last 30 days
- Inability to understand and/or follow research procedures due to mental, cognitive, or emotional disorders
- Hemoglobin <90g/L %
- Permanent hypertension
- Subjects who were judged by the investigator to be unsuitable for this clinical study
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Interventions
Day 1, loading dose of tiprogrel and loading dose of aspirin; Day 2-90, daily maintenance dose of tiprogrel and daily maintenance dose of aspirin.
Drug: Tiprogrel and Aspirin Day 1, loading dose of tiprogrel and loading dose of aspirin; Day 2-90, daily maintenance dose of tiprogrel and daily maintenance dose of aspirin.
Day 1, loading dose of Clopidogrel and loading dose of aspirin; Day 2-21, daily maintenance dose of Clopidogrel and daily maintenance dose of aspirin; D22-90: daily maintenance dose of Clopidogrel.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06601127