RecruitingPhase 2NCT06601465
COgnitioN With VERiciGuat Evaluation in Heart Failure
CONVERGE-HF: COgnitioN With VERiciGuat Evaluation in Heart Failure
Sponsor
University of Alberta
Enrollment
120 participants
Start Date
Jun 3, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
CONVERGE-HF is a 4-center pilot phase IIb randomized control trial in ambulatory patients with chronic heart failure (≥ 6 months) and mild-to-moderate cognitive impairment.
Eligibility
Min Age: 18 Years
Plain Language Summary
Simplified for easier understanding
This study is testing whether a heart failure medication called vericiguat — which relaxes blood vessels — can also improve mild to moderate cognitive impairment (thinking and memory problems) that often occurs alongside chronic heart failure.
**You may be eligible if...**
- You are an adult
- You have had chronic heart failure for at least 6 months
- You have been diagnosed with mild to moderate cognitive impairment, or you scored between 10 and 25 on the Montreal Cognitive Assessment (MoCA)
**You may NOT be eligible if...**
- You take long-acting nitrates or certain other medications (riociguat, PDE-5 inhibitors like sildenafil)
- You are pregnant or breastfeeding
- You are unable to undergo cardiac MRI or brain MRI
- You have an implanted heart device (pacemaker, defibrillator) incompatible with MRI
- You have uncontrolled atrial fibrillation or serious recurring heart rhythm problems
- You have uncontrolled thyroid disease, liver failure, cancer, or severe dementia
- You recently had heart bypass surgery or angioplasty (within the past 3 months)
- You are currently hospitalised
Talk to your doctor to see if this trial is right for you.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
DRUGVericiguat
Tablet - 2.5 mg, 5 mg, 10 mg
Locations(4)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06601465
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