RecruitingPhase 2NCT06601465

COgnitioN With VERiciGuat Evaluation in Heart Failure

CONVERGE-HF: COgnitioN With VERiciGuat Evaluation in Heart Failure


Sponsor

University of Alberta

Enrollment

120 participants

Start Date

Jun 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

CONVERGE-HF is a 4-center pilot phase IIb randomized control trial in ambulatory patients with chronic heart failure (≥ 6 months) and mild-to-moderate cognitive impairment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a heart failure medication called vericiguat — which relaxes blood vessels — can also improve mild to moderate cognitive impairment (thinking and memory problems) that often occurs alongside chronic heart failure. **You may be eligible if...** - You are an adult - You have had chronic heart failure for at least 6 months - You have been diagnosed with mild to moderate cognitive impairment, or you scored between 10 and 25 on the Montreal Cognitive Assessment (MoCA) **You may NOT be eligible if...** - You take long-acting nitrates or certain other medications (riociguat, PDE-5 inhibitors like sildenafil) - You are pregnant or breastfeeding - You are unable to undergo cardiac MRI or brain MRI - You have an implanted heart device (pacemaker, defibrillator) incompatible with MRI - You have uncontrolled atrial fibrillation or serious recurring heart rhythm problems - You have uncontrolled thyroid disease, liver failure, cancer, or severe dementia - You recently had heart bypass surgery or angioplasty (within the past 3 months) - You are currently hospitalised Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGVericiguat

Tablet - 2.5 mg, 5 mg, 10 mg


Locations(4)

University of Calgary

Calgary, Alberta, Canada

University of Alberta

Edmonton, Alberta, Canada

University of Ottawa

Ottawa, Ontario, Canada

McGill University Health Center

Montreal, Quebec, Canada

View Full Details on ClinicalTrials.gov

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NCT06601465


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