Cellular Markers in Treated or Untreated Non-tuberculous Mycobacterial Respiratory Infection in Patients With Cystic Fibrosis
Cellular Markers During a Non-tuberculous Mycobacterial Respiratory Infection, Treated or Untreated, in Patients With Cystic Fibrosis
University Hospital, Montpellier
76 participants
Sep 17, 2024
OBSERVATIONAL
Conditions
Summary
This study evaluates a diagnostic serological test for Non-Tuberculous Mycobacteria (NTM) infection in cystic fibrosis patients by measuring T cell response. It aims to highlight a dynamic response associated to the pathogen's presence. This multicenter case-control study involves two populations, providing a better understanding of the circulating T-IFNγ-MNT response in these patients.
Eligibility
Inclusion Criteria6
- Patient ≥18 years
- Patient previously included in the CIMeNT study
- Patient with a confirmed diagnosis of cystic fibrosis regardless of CFTR genotype
- Patient affiliated to the social security system
- Patient registered in the French Cystic Fibrosis Registry
- Adult patient capable of spontaneous expectoration or after induction
Exclusion Criteria3
- Lung transplant patients
- Person placed under judicial protection
- Pregnant and breastfeeding women
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Interventions
During the scheduled visit (V1), as part of routine care, a blood draw will be performed. On this occasion, an additional 7 ml tube will be collected to perform serology and culture. This will help define the group (NTM+ Cases/NTM- Controls) and measure cellular biomarkers.
Locations(1)
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NCT06602869