RecruitingPhase 2NCT06604260

FAPi-PET Imaging of in Vivo Fibrosis in Inflammatory Bowel Disease Patients

Sponsor

Dalia Lartey

Enrollment

20 participants

Start Date

Aug 31, 2023

Study Type

INTERVENTIONAL

Conditions

IBD (Inflammatory Bowel Disease)Ulcerative Colitis (UC)Crohn Disease (CD)

Summary

Our main objective is to evaluate the feasibility of 68Ga-FAPi PET/CT in detecting intestinal fibrosis in patients with IBD. To this end, we will determine 68Ga-FAPi uptake in IBD in relation to cellular FAP expression in intestinal biopsies and resection specimens.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses a special type of PET scan — a whole-body imaging tool — to detect scarring (fibrosis) in the intestines of people with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. The scan looks for a protein called FAP that marks areas of active scarring. This could help doctors better understand how much gut damage has occurred and guide treatment decisions. **You may be eligible if...** - You are 18 years or older - You have a confirmed diagnosis of Crohn's disease OR ulcerative colitis - Your disease is currently active, shown by symptoms, blood/stool tests, endoscopy, or imaging **You may NOT be eligible if...** - You are pregnant - You cannot give informed consent - You have had IBD-related surgery in the past 5 years - You have colorectal cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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