Ulcerative Colitis (UC) Clinical Trials

45 recruiting

Frequently Asked Questions

Common questions about Ulcerative Colitis (UC) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 47 trials

Recruiting

Zymfentra (Infliximab-dyyb) REal World Cohort STudy

Ulcerative Colitis (UC)Inflammatory Bowel Disease (IBD)Indeterminate Colitis+1 more
University of North Carolina, Chapel Hill200 enrolled5 locationsNCT07237516
Recruiting

Prospective Evaluation of the Carbon Footprint and Clinical Utility of IBUS Compared to Colonoscopy and Enterography in UC and CD

Ulcerative Colitis (UC)Crohns Disease
Asian Institute of Gastroenterology, India200 enrolled2 locationsNCT07431983
Recruiting

Effectiveness of Ozanimod in Patients With Steroid-Dependent Ulcerative Colitis

Ulcerative Colitis (UC)
Bristol-Myers Squibb150 enrolled17 locationsNCT07271069
Recruiting
Phase 2

Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease

Crohn DiseaseUlcerative Colitis (UC)IBD
Assistance Publique - Hôpitaux de Paris45 enrolled1 locationNCT07300553
Recruiting
Phase 2

A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease

Crohn's DiseaseUlcerative Colitis (UC)Inflammatory Bowel Disease (IBD)
Mirador Therapeutics, Inc.140 enrolled66 locationsNCT07113522
Recruiting
Phase 1Phase 2

Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

Ulcerative Colitis (UC)
Xencor, Inc.270 enrolled40 locationsNCT06619990
Recruiting
Phase 2

A Study for HSK47388 in Participants With Ulcerative Colitis

Ulcerative Colitis (UC)
Haisco Pharmaceutical Group Co., Ltd.150 enrolled1 locationNCT07335055
Recruiting

Real-World Effectiveness and Safety of Upadacitinib Plus Vedolizumab vs Upadacitinib Monotherapy During Induction in Moderate-to-Severe Ulcerative Colitis

Ulcerative Colitis (UC)
Sixth Affiliated Hospital, Sun Yat-sen University150 enrolled1 locationNCT07442045
Recruiting

Switching to the IL-23 Inhibitor Guselkumab for People With Active IBD Who Previously Used Ustekinumab (SHIFT-IBD)

Ulcerative Colitis (UC)Crohn Disease (CD)Inflammatory Bowel Disease (IBD)+1 more
TIDHI Innovation Inc.200 enrolled9 locationsNCT07245394
Recruiting
Phase 2

Safety and Efficacy of OD-07656 and of Subsequent Vedolizumab Therapy in Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis (UC)UC - Ulcerative Colitis
Odyssey Therapeutics57 enrolled32 locationsNCT06850727
Recruiting
Phase 2

Desloratadine in Patients With Ulcerative Colitis

Ulcerative ColitisUlcerative Colitis (UC)
Tanta University44 enrolled1 locationNCT07333716
Recruiting
Not Applicable

Impact of Exclusion Diet in Addition to Anti-TNF Therapy in Crohn's Disease and Ulcerative Colitis: a Prospective, Randomized, Double-arm, Open-label Study

Ulcerative Colitis (UC)Crohn Disease (CD)
IRCCS Ospedale San Raffaele80 enrolled1 locationNCT06896305
Recruiting

TRIOCOL - The Study of Continued Advanced Medical Therapy or Colectomy in Patients With Ulcerative Colitis

Ulcerative Colitis (UC)
Region Stockholm500 enrolled1 locationNCT07347834
Recruiting
Phase 1

Evaluate the Safety, Tolerability, PK and PD of SAD of Intravenously Adminsterted ALTB-268 in Healthy Participants

Ulcerative Colitis (UC)
AltruBio Inc.24 enrolled1 locationNCT07350577
Recruiting

CEDUR - German IBD Registry

Ulcerative Colitis (UC)Crohn Disease (CD)Indeterminate Colitis
ImmunoRegister gUG10,000 enrolled1 locationNCT07319442
Recruiting
Phase 4

De-escalation of Ustekinumab Therapy in Patients With Crohn's Disease and Ulcerative Colitis

Ulcerative Colitis (UC)Crohn Disease (CD)
McGill University Health Centre/Research Institute of the McGill University Health Centre115 enrolled1 locationNCT07303686
Recruiting
Not Applicable

Oral Vitamin D3 Effect on Inflammatory Biomarkers in Ulcerative Colitis Patients

Ulcerative Colitis (UC)
University of Veterinary and Animal Sciences, Lahore - Pakistan60 enrolled1 locationNCT07269223
Recruiting
Phase 4

Efficacy of Top-down Therapy With Mirikizumab Versus Standard of Care With Azathioprine in Patients With Newly Diagnosed Moderate-to-severe Ulcerative Colitis

Ulcerative Colitis (UC)
University Hospital Schleswig-Holstein300 enrolled1 locationNCT07235904
Recruiting

Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics

Ulcerative Colitis (UC)Crohn Disease (CD)Autism Spectrum Disorder+6 more
Chen QiYi4,000 enrolled1 locationNCT07261826
Recruiting
Not Applicable

Evaluation of the SMART IBD App in Pediatric IBD

IBD (Inflammatory Bowel Disease)Ulcerative Colitis (UC)Crohn Disease (CD)+3 more
Children's Hospital Medical Center, Cincinnati70 enrolled1 locationNCT07195123