RecruitingNCT06605404

Pan-tumor MRD Study

Molecular Residual Disease in Solid Tumors: A Prospective Study to Collect Clinical Data and Biospecimens to Support Discovery and Development of Cancer Biomarkers


Sponsor

Paradigm Health

Enrollment

1,350 participants

Start Date

Jan 8, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this observational study is to collect clinical information, blood, and tumor tissue samples from participants diagnosed with stage I, stage II, or operable stage III cancer in select solid tumors. The information collected will be used to develop tests to better understand cancer, for example, to improve cancer detection and to assess the risk of cancer coming back. Participants will receive routine standard of care from their doctor and their involvement is expected to last for approximately five and a half (5.5) years.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a blood test that detects tiny fragments of tumor DNA — called circulating tumor DNA (ctDNA) — can track whether cancer is still present after surgery. This approach, called minimal residual disease (MRD) testing, could help doctors decide whether additional treatment is needed. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with a solid tumor cancer (specific types or those meeting broad eligibility) - You are planning to have surgery with the goal of curing your cancer - You enrolled within 3 months of surgery and before starting any additional treatments like chemotherapy - You are otherwise in good health and able to complete study procedures including blood draws and providing tumor tissue **You may NOT be eligible if...** - You have already received systemic therapy (chemotherapy, immunotherapy, etc.) for your current cancer - You are unable to cooperate with required procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTblood and tissue samples

routine standard of care

OTHERblood and tissue samples

Routine standard of care


Locations(2)

Medical Oncology Associates of San Diego

San Diego, California, United States

Taylor Cancer Research Center

Maumee, Ohio, United States

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NCT06605404


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