Melanoma (Skin Cancer) Clinical Trials

17 recruiting

Melanoma (Skin Cancer) Trials at a Glance

17 actively recruiting trials for melanoma (skin cancer) are listed on ClinicalTrialsFinder across 6 cities in 11 countries. The largest study group is Phase 2 with 5 trials, with the heaviest enrollment activity in Madison, Nashville, and Barcelona. Lead sponsors running melanoma (skin cancer) studies include Fundacion Clinic per a la Recerca Biomédica, Fondazione del Piemonte per l'Oncologia, and Aminex Therapeutics, Inc..

Browse melanoma (skin cancer) trials by phase

Treatments under study

About Melanoma (Skin Cancer) Clinical Trials

Looking for clinical trials for Melanoma (Skin Cancer)? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Melanoma (Skin Cancer) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Melanoma (Skin Cancer) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Not Applicable

Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy

Melanoma (Skin Cancer)Renal Cell Carcinoma (Kidney Cancer)Breast Cancer (Triple Negative Breast Cancer (TNBC))
Jessica Mezzanotte Sharpe25 enrolled1 locationNCT07555210
Recruiting
Phase 2Phase 3

A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

Unresectable MelanomaCutaneous MelanomaMelanoma (Skin Cancer)+1 more
Linnaeus Therapeutics, Inc.135 enrolled9 locationsNCT06624644
Recruiting
Phase 1

Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)

Breast CancerMelanoma (Skin Cancer)Brain Metastasases
M.D. Anderson Cancer Center50 enrolled1 locationNCT06545682
Recruiting
Phase 3

NO Re-excision MelanomA - NORMA 2

Melanoma (Skin Cancer)
Marieke Goodijk1,749 enrolled21 locationsNCT07530887
Recruiting
Phase 1Phase 2

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

Melanoma (Skin Cancer)HER2-low Hormone Receptor Positive Breast Cancer
Aminex Therapeutics, Inc.92 enrolled8 locationsNCT07287917
Recruiting

A Study of Biological, Genetic, and Constitutional Factors and Non-invasive Monitoring to Assess Personal Cancer Risks

Breast CancerOvarian CancerColo-rectal Cancer+2 more
Fondazione del Piemonte per l'Oncologia850 enrolled1 locationNCT07469709
Recruiting
Phase 2

A Phase II Clinical Trial on Neo-adjuvant Pembrolizumab in Patients With pT3b-T4a/b cN0M0 Melanoma.

Melanoma (Skin Cancer)
Universitair Ziekenhuis Brussel49 enrolled1 locationNCT07448831
Recruiting

IMmune checkPoint Inhibitor Related gonAdal toxiCiTy in Premenopausal Women and Men With Melanoma

Melanoma (Skin Cancer)
Peter MacCallum Cancer Centre, Australia80 enrolled6 locationsNCT07138222
Recruiting
Phase 1

A Phase 1 Study of TGI-5 as Monotherapy and in Combination With Nivolumab in Subjects With Locally Advanced/Metastatic Solid Tumors

Melanoma (Skin Cancer)NSCLC (Non-small Cell Lung Cancer)CRC (Colorectal Cancer)+1 more
Hefei TG ImmunoPharma Co., Ltd.194 enrolled1 locationNCT07376707
Recruiting
Phase 2

Neoadjuvant Pembrolizumab in Patients With Stage IIb/c Melanoma

Melanoma (Skin Cancer)
Vastra Gotaland Region30 enrolled1 locationNCT07349303
Recruiting
Phase 2

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma

Metastatic MelanomaUnresectable MelanomaMelanoma (Skin Cancer)
Iovance Biotherapeutics, Inc.100 enrolled5 locationsNCT07288203
Recruiting

Liquid Biomarker Study in Melanoma and Non-Melanoma Skin Cancers

Skin CancerMelanoma (Skin Cancer)Merkel Cell Carcinoma of Skin+3 more
University of Wisconsin, Madison20 enrolled1 locationNCT06608511
Recruiting

Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions

Melanoma (Skin Cancer)Next Generation Sequencing (NGS)Melanocytic Nevi
University of Modena and Reggio Emilia200 enrolled1 locationNCT07277920
Recruiting

Pan-tumor MRD Study

Esophageal CancerMelanoma (Skin Cancer)NSCLC (Non-small Cell Lung Cancer)+4 more
Paradigm Health1,350 enrolled2 locationsNCT06605404
Recruiting

Precision Medicine for L/GCMN and Melanoma 1

Melanoma (Skin Cancer)Nevi and Melanomas
Fundacion Clinic per a la Recerca Biomédica6,000 enrolled1 locationNCT06608420
Recruiting

Precision Medicine for L/GCMN and Melanoma 2

Melanoma (Skin Cancer)Nevi and MelanomasCongenital Melanocytic Nevus
Fundacion Clinic per a la Recerca Biomédica100 enrolled3 locationsNCT06605443
Recruiting

Artificial Intelligence Based Melanoma Early Diagnosis and Risk Prediction in Children, Adolescents and Young Adults

Melanoma (Skin Cancer)Artificial Intelligence (AI)Pediatric Cancer
German Cancer Research Center3,000 enrolled3 locationsNCT06621810