Immunity Markers in Intensive Care Patients and Ventilator-associated Pneumonia
Monitoring of Immunity Markers in Intensive Care Patients and Link with Recurrence and Relapse of Ventilator-associated Pneumonia
Centre Hospitalier Intercommunal Aix-Pertuis
40 participants
Oct 4, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to show the direct correlation between the occurrence of recurrence of VAP and postagressive immunoparalysis, monitored by HLA-DR rate below litterature-acknowledged threshold, in a well conducted antibiotherapy context, in patient admitted in the Intensive Care Unit. The main questions it aims to answer are: * evaluation of the association between death and persistence of immunoplegia using HLA-DR monitoring * search an association between immunoplegia depth and severity of the initial state of shock * search an association between immunoplegia depth and viral reactivation * compare association of immunoplegia duration and HLA-DR nadir and VAP occurrence Blood samples will be taken from participants to HLA-DR dosage, at the time of inclusion and once a week then.
Eligibility
Plain Language Summary
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Interventions
HLA-DR dosage, at the time of inclusion and once a week then
Locations(1)
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NCT06607055