RecruitingNCT06607055

Immunity Markers in Intensive Care Patients and Ventilator-associated Pneumonia

Monitoring of Immunity Markers in Intensive Care Patients and Link with Recurrence and Relapse of Ventilator-associated Pneumonia


Sponsor

Centre Hospitalier Intercommunal Aix-Pertuis

Enrollment

40 participants

Start Date

Oct 4, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to show the direct correlation between the occurrence of recurrence of VAP and postagressive immunoparalysis, monitored by HLA-DR rate below litterature-acknowledged threshold, in a well conducted antibiotherapy context, in patient admitted in the Intensive Care Unit. The main questions it aims to answer are: * evaluation of the association between death and persistence of immunoplegia using HLA-DR monitoring * search an association between immunoplegia depth and severity of the initial state of shock * search an association between immunoplegia depth and viral reactivation * compare association of immunoplegia duration and HLA-DR nadir and VAP occurrence Blood samples will be taken from participants to HLA-DR dosage, at the time of inclusion and once a week then.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Blood collection for people with pneumonia, ventilator-associated. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTBlood collection

HLA-DR dosage, at the time of inclusion and once a week then


Locations(1)

Centre Hospitalier Intercommunal Aix-Pertuis

Aix-en-Provence, France

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NCT06607055


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