RecruitingNot ApplicableNCT06608797

Testing the Feasibility of Computer-based Cognitive Training in Individuals with Multiple Sclerosis Living in the Community

Sponsor

Kessler Foundation

Enrollment

40 participants

Start Date

Sep 30, 2024

Study Type

INTERVENTIONAL

Conditions

Multiple Sclerosis

Summary

Cognitive impairments are common in multiple sclerosis (MS) diagnosed both at the onset and throughout the disease course. Poor cognitive abilities have been associated with poor outcomes such as higher levels of unemployment, poor quality of life, driving difficulties among others. Learning and memory are a common cognitive deficit. This computer-based cognitive training is a 10-session treatment proven to be effective in ameliorating learning and memory in individuals with MS across 3 realms of functioning: objective cognitive performance, daily life activities and neuroimaging. Despite this strong efficacy, as well as the recent clinical application of this computer-based cognitive training across the world, recent in-person studies have highlighted that transportation to the clinic to complete treatment sessions is a significant obstacle to clinical use of this effective treatment. To address this limitation, the proposed pilot study will test the efficacy of the computer-based cognitive training administered remotely via zoom health in persons with multiple sclerosis.

Eligibility

Min Age: 19 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a computer-based brain training program is practical and helpful for people with multiple sclerosis (MS) who live in the community and experience memory or thinking difficulties. The program is delivered via computer and aims to improve cognitive function in everyday life. **You may be eligible if...** - You have a diagnosis of multiple sclerosis - English is your primary language - You show signs of memory or learning difficulties on a cognitive test **You may NOT be eligible if...** - You had an MS relapse (flare-up) within the past month - You have a history of head injury, stroke, seizures, or other significant neurological conditions - You have active major depression, schizophrenia, or bipolar disorder - You have poor vision that is not well corrected (double vision or involuntary eye movements) - You cannot follow multi-step instructions - Your memory and learning are testing as fully intact Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALLearning and memory training

The experimental group will receive memory retraining exercises administered on a laptop computer via Zoom Health twice a week for five weeks (10 training sessions).

BEHAVIORALSham Comparator

The sham comparator group will receive sham memory exercises administered on a laptop computer via Zoom Health twice a week for five weeks (10 placebo control sessions).