RecruitingPhase 1NCT06609109

Effect of Cannabis on E-Cigarette Use Behavior

Effect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics: Electronic Cigarette Use


Sponsor

Johns Hopkins University

Enrollment

100 participants

Start Date

Mar 19, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes. The study's goals are to test demand for e-cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke e-cigarettes and either smoke or vape THC in the laboratory.


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called E-Cigarette Full Nicotine, a drug called E-Cigarette Placebo Nicotine, and others for people with cannabis use, electronic cigarette use, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTHC High Dose

Low dose of THC (30 mg)

DRUGTHC Low Dose

Low dose of THC (5 mg)

DRUGTHC 0mg

Placebo dose of THC (0 mg)

DRUGE-Cigarette Full Nicotine

E-Cigarette with Nicotine

DRUGE-Cigarette Placebo Nicotine

E-Cigarette with No Nicotine


Locations(1)

Johns Hopkins University Behavioral Pharmacology Research Unit

Baltimore, Maryland, United States

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NCT06609109


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