Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Intravenous Acetaminophen After Cardiac Surgery
McGill University Health Centre/Research Institute of the McGill University Health Centre
1,100 participants
Jul 2, 2024
INTERVENTIONAL
Conditions
Summary
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.
Eligibility
Inclusion Criteria4
- greater or equal to 18
- elective cardiac surgery
- stable pre-operative
- aorto-coronary bypass with or without 1 valve replacement.
Exclusion Criteria2
- Refusal by surgeon Requested late extubation by surgeon or anesthesia Intra-aortic balloon pump Mechanical cardiac support Sensitivity to acetaminophen Psychiatric history with current active treatment Alzheimer\'s disease Seizure in previous 6 months Recent history of alcohol misuse Cognitive impairment
- \-
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Interventions
Patient receive IV acetaminophen (and oral placebo) or placebo IV acetaminophen and oral acetaminophen. All drugs are blinded
Locations(8)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06613178