Study of Oral PCLX-001 in R/R Acute Myeloid Leukemia

This study tests an oral drug called PCLX-001 in people with relapsed or refractory acute myeloid leukemia (AML) — meaning their leukemia has come back or stopped responding to prior treatments. The drug works by blocking a specific enzyme that leukemia cells depend on to survive. **You may be eligible if...** - You are an adult (18 or older) - You have been diagnosed with AML that has come back or has not responded to prior treatment - You have had at least one prior course of AML treatment - You are in adequate physical health with acceptable blood counts and organ function **You may NOT be eligible if...** - You have active, serious infections - You have certain heart rhythm problems (like prolonged QTc interval) - You have significant liver or kidney impairment - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.