Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants

This study tests a new home hemodialysis system called Moda-flx, which is designed to allow patients with end-stage kidney disease to do their dialysis at home rather than traveling to a clinic multiple times per week. The study evaluates both professional-setting use and safe home use with a trained care partner. **You may be eligible if...** - You are between 18 and 80 years old, and your care partner is at least 18 years old - You have end-stage kidney disease and are already receiving maintenance dialysis - Your dialysis is currently adequate (meeting standard treatment targets) - You have a willing and available care partner **You may NOT be eligible if...** - You have had a recent hospitalization or major health event making home dialysis unsafe - You have certain vascular access issues - You are unable to train with a care partner or manage home use - You are pregnant Talk to your doctor to see if this trial is right for you.