A Trial of a Gorilla Adenovirus Vectored Networked Epitopes Vaccine, Administered to Healthy Adults Living Without and With HIV.

This trial is testing a new vaccine — delivered using a modified gorilla adenovirus as a carrier — designed to help the immune system recognize and fight HIV. The vaccine is being tested in both HIV-negative healthy adults and HIV-positive adults to assess safety and how well it generates an immune response. **You may be eligible if...** - You are between 18 and 50 years old - You are in generally good health - You are willing to comply with study requirements and follow-up visits - If you could become pregnant, you are committed to using effective contraception throughout the study - You have read and understood the information about the study and its risks **You may NOT be eligible if...** - You have significant health conditions that could interfere with your participation or safety - You are pregnant or planning to become pregnant without using contraception - You have had certain prior vaccines or treatments that could interfere with results Talk to your doctor to see if this trial is right for you.