RecruitingNot ApplicableNCT06617845

Optimizing Brain Stimulation Parameters

Sponsor

Mayo Clinic

Enrollment

30 participants

Start Date

Oct 20, 2020

Study Type

INTERVENTIONAL

Conditions

Epilepsy; Seizure

Summary

A primary purpose of this study is to better understand what stimulation parameters work best for patients. For example, for Deep Brain Stimulation (DBS) of the Anterior Nucleus of the Thalamus (ANT), it is not clear what stimulation frequency leads is most effective. This study will help assess the effectiveness of low frequency or high frequency stimulation.

Eligibility

Min Age: 6 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how to fine-tune the settings of a brain stimulation device (similar to a pacemaker for the brain) that is implanted in a specific brain region called the anterior nucleus of the thalamus. This device is used to help control seizures in patients with epilepsy. The study aims to find the best stimulation settings for each patient. **You may be eligible if...** - You have already had a brain stimulation device surgically implanted targeting the anterior nucleus of the thalamus as part of your standard care at Mayo Clinic **You may NOT be eligible if...** - You are not expected to have regular clinical follow-up appointments in the first 6 to 8 months after your implant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEStimulation Set A and B

Subjects will receive one stimulation parameter set first for 3 months and then the other for three months. Sets will include Set A (145 Hz high frequency stimulation) and Set B (Low frequency stimulation less than 40 Hz, which is similar to stimulation frequencies used during cortical stimulation). The 145 Hz stimulation will be set to cycling (1 min on, 5 min off) while the low frequency setting will be continuous. Both sets include stimulation parameter sets that have been used in clinical practice as a part of standard of care. However, it is unclear which set is better or whether they are similarly effective.