Prospective Collection of Samples to Enable the Development of Natera Screening Assay for Early Cancer Detection

This study is collecting blood samples from people who are already scheduled for a routine screening colonoscopy, in order to develop and test a new early cancer detection blood test (a liquid biopsy screening assay). The goal is to see whether a blood test can detect early colorectal cancer or precancerous growths before they show symptoms. **You may be eligible if...** - You are 40 years of age or older - You are planning to undergo a routine, asymptomatic (screening) colonoscopy — meaning you have no symptoms - You are able to tolerate having blood drawn for research - You can provide blood samples within 120 days before your colonoscopy - You have not had a colonoscopy in the recent past (per study criteria) **You may NOT be eligible if...** - You have any prior history of cancer (except skin basal cell or squamous cell cancer removed at least 12 months ago) - You had a complete colonoscopy recently (within the required timeframe) - You have symptoms that prompted the colonoscopy (this is only for asymptomatic screening) Talk to your doctor to see if this trial is right for you.