Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV

This study looks at how the Gardasil 9 HPV vaccine works in people with and without HIV, specifically in individuals who were born male and may have used hormone therapy. Researchers want to understand whether HIV status or hormone exposure affects how the body responds to the HPV vaccine. **You may be eligible if...** - You were born male and are between 18 and 70 years old - You have never received the Gardasil 9 HPV vaccine (or are unsure and were born before 2003) - You are living with HIV and have used androgen blockers or estrogen (past or present), OR - You are HIV-negative and have had sex with a person with a penis in the past year, or have used hormone therapy **You may NOT be eligible if...** - You were born female - You have already received the Gardasil 9 HPV vaccine (and were born after 2003) - You have had a severe allergic reaction to yeast or vaccine ingredients - You are currently receiving chemotherapy, immunotherapy, IV immunoglobulin, or radiation Talk to your doctor to see if this trial is right for you.