RecruitingEarly Phase 1NCT06624904

Losartan and Social Processing

The Effects of Single-dose Losartan on Social Processing in Healthy Adults: a Randomized Controlled Study

Sponsor

University of Oxford

Enrollment

68 participants

Start Date

Aug 19, 2024

Study Type

INTERVENTIONAL

Conditions

Social Cognition

Summary

This study explores the effects of single-dose losartan (50mg) versus placebo on social processing in healthy volunteers.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria5

Willing and able to provide informed consent
Aged 18-50 years
Sufficient written and spoken English skills to understand what the study involves, and to complete the questionnaires
Non- or light-smoker (5 cigarettes a day, if vaping: less than 50 puffs)
BMI between 18 - 30

Exclusion Criteria12

Current DSM-5 axis-I diagnosis (based on SCID results at screening) or history of a severe psychological disorder such as psychotic disorder, bipolar disorder, alcohol or substance abuse, or post-traumatic stress disorder
First-degree family member with severe psychiatric illness (including psychosis, bipolar disorder, unipolar psychotic depression).
CNS-medication last 6 weeks (including as part of another study)
Current blood pressure or other heart medication, including aliskiren and beta blockers)
Diagnosis of intravascular fluid depletion or dehydration
History of angioedema
Impaired kidney function (based on self-report)
Very low blood pressure (defined as repeated (at least three consecutive measurements) measures of blood pressure under standardised conditions where either the systolic or the diastolic blood pressure or both are below 90/50 mmHg (in accordance with established standard definitions)
Lifetime history of epilepsy or other neurological disorder, as established by a professional diagnosis (e.g. autism, ADHD)
Lifetime history of systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study
Significant loss of hearing that is not corrected with a hearing device
Women: pregnancy (as determined by a urine test, if the participant's pregnancy status is unknown during the in-person visit), breast-feeding