Study of Atrial Fibrillation Combined with Atrial Functional Mitral Regurgitation

This study is examining the link between atrial fibrillation (an irregular heartbeat) and a type of mitral valve problem called atrial functional mitral regurgitation, where the valve leaks because the heart chamber has enlarged. Researchers want to better understand how to treat both conditions together. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with symptomatic paroxysmal atrial fibrillation (episodes of irregular heartbeat, with less than 5 years of history) - You have moderate to severe mitral valve leakage with a normally functioning left ventricle **You may NOT be eligible if...** - Your atrial fibrillation is caused by thyroid problems or other reversible causes - You have active heart valve infection or rheumatic heart disease - You have moderate to severe narrowing of the mitral valve - You have a clot in your heart or heart chamber - You have a pacemaker, defibrillator, or CRT device already implanted - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.