Atrial Fibrillation (AF) Clinical Trials

109 recruitingLast updated: June 18, 2026

There are 109 actively recruiting atrial fibrillation (af) clinical trials across 50 countries. Studies span Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4. Top locations include Beijing, Beijing Municipality, China, Boston, Massachusetts, United States, Guangzhou, Guangdong, China. Updated daily from ClinicalTrials.gov.


Atrial Fibrillation (AF) Trials at a Glance

109 actively recruiting trials for atrial fibrillation (af) are listed on ClinicalTrialsFinder across 6 cities in 50 countries. The largest study group is Not Applicable with 70 trials, with the heaviest enrollment activity in Beijing, Boston, and Guangzhou. Lead sponsors running atrial fibrillation (af) studies include Beijing Anzhen Hospital, China National Center for Cardiovascular Diseases, and University of California, San Francisco.

Browse atrial fibrillation (af) trials by phase

Treatments under study

About Atrial Fibrillation (AF) Clinical Trials

Looking for clinical trials for Atrial Fibrillation (AF)? There are currently 107 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Atrial Fibrillation (AF) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Atrial Fibrillation (AF) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 109 trials

Recruiting
Phase 2

Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation

Atrial Fibrillation (AF)
Regeneron Pharmaceuticals1,200 enrolled48 locationsNCT07175428
Recruiting
Not Applicable

Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation

Atrial Fibrillation (AF)
China National Center for Cardiovascular Diseases200 enrolled1 locationNCT07630857
Recruiting
Not Applicable

Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation

Sleep-disordered breathing (SDB)Obstructive Sleep ApneaArrhythmia+3 more
Beijing Anzhen Hospital658 enrolled27 locationsNCT07444372
Recruiting

Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation

Atrial Fibrillation (AF)
University of Edinburgh300 enrolled1 locationNCT06951100
Recruiting

Left Atrial and Left Ventricular Structural and Functional Evaluation by CCTA for Predicting Post-Ablation Outcomes in Patients With Atrial Fibrillation

Atrial Fibrillation (AF)
Nanjing First Hospital, Nanjing Medical University600 enrolled1 locationNCT07651046
Recruiting
Phase 2

Clinical Phase 2 Trial of AP31969 Versus Placebo for Rhythm Control of Atrial Fibrillation

Atrial Fibrillation (AF)
Acesion Pharma200 enrolled44 locationsNCT07267949
Recruiting
Not Applicable

Evaluating the Impact of Home-Based Sleep Apnea Diagnostic on Well-Being, Health Behavior, and AF Load in Patients With Atrial Fibrillation Using a Decentralized Platform

Sleep ApneaAtrial Fibrillation (AF)
Herlev and Gentofte Hospital936 enrolled1 locationNCT06618417
Recruiting
Not Applicable

Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED)

Atrial Fibrillation (AF)Atrial Flutter
Ottawa Heart Institute Research Corporation190 enrolled3 locationsNCT07002450
Recruiting
Not Applicable

Prediction of Atrial Fibrillation Using Polygenic Risk Score

Atrial Fibrillation (AF)
Seoul St. Mary's Hospital800 enrolled5 locationsNCT07641582
Recruiting
Not Applicable

Cardiac Arrhythmia Telemetry; Conventional vs HeartWatch

Atrial Fibrillation (AF)Cardiac ArrhythmiaDiagnostic/Monitoring Devices Related to Adverse Incidents
HelpWear Inc.300 enrolled1 locationNCT06164808
Recruiting
Not Applicable

Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation

StrokeFrailtyAtrial Fibrillation (AF)+4 more
Guangdong Provincial People's Hospital200 enrolled1 locationNCT07441382
Recruiting
Not Applicable

Identification of the Metabolic Signature of Atrial Fibrillation for Personalized Prevention

Atrial Fibrillation (AF)
University Hospital, Bordeaux400 enrolled1 locationNCT06735001
Recruiting
Not Applicable

Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

Atrial Fibrillation (AF)Persistant Atrial FibrillationParoxysmal AF
Arga Medtech SA360 enrolled27 locationsNCT06784466
Recruiting
Early Phase 1

Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation

Atrial Fibrillation (AF)
China National Center for Cardiovascular Diseases3,160 enrolled12 locationsNCT06615596
Recruiting

Complex Arrhythmia Registry

Atrial Fibrillation (AF)Ventricular Tachycardia (VT)
Beijing Anzhen Hospital4,000 enrolled2 locationsNCT07024927
Recruiting
Not Applicable

Comparative Evaluation of Optrell and Octaray Mapping Catheters for Conduction Block Confirmation and Voltage Assessment During Atrial Ablation

Atrial Fibrillation (AF)
Maxime Zabern30 enrolled1 locationNCT07563257
Recruiting
Not Applicable

Sex-Based Disparities in the Electrophysiological Substrate for Atrial Fibrillation and Its Impact on Clinical Outcomes

Atrial Fibrillation (AF)
Anat Milman100 enrolled1 locationNCT07580547
Recruiting
Not Applicable

Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study

Atrial Fibrillation (AF)
Northwell Health50 enrolled1 locationNCT07620262
Recruiting

Efficacy of Early Rhythm Control in AF With TR Patients

Atrial Fibrillation (AF)Tricuspid Regurgitation (TR)
Samsung Medical Center5,800 enrolled1 locationNCT07607093
Recruiting
Not Applicable

A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

Atrial Fibrillation (AF)Persistant Atrial Fibrillation
Boston Scientific Corporation699 enrolled41 locationsNCT07187115