Atrial Fibrillation (AF) Clinical Trials

80 recruiting

Frequently Asked Questions

Common questions about Atrial Fibrillation (AF) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 81 trials

Recruiting

COCONUT Study Concomitant PVI and LAAC

Atrial Fibrillation (AF)
Asklepios proresearch60 enrolled1 locationNCT06861673
Recruiting
Not Applicable

Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

Atrial Fibrillation (AF)Persistant Atrial FibrillationParoxysmal AF
Arga Medtech SA360 enrolled26 locationsNCT06784466
Recruiting
Phase 2

Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation

Atrial Fibrillation (AF)
Regeneron Pharmaceuticals1,200 enrolled37 locationsNCT07175428
Recruiting

LA Function After PFA in Paroxysmal AF

Atrial Fibrillation (AF)
Charles University, Czech Republic50 enrolled1 locationNCT07439016
Recruiting
Not Applicable

Comparative Intra-procedural Evaluation of Farapulse and FARAWAVE Nav Catheters

Atrial Fibrillation (AF)Atrial Fibrillation AblationPulsed Field Ablation
Cardiocentro Ticino58 enrolled1 locationNCT07130773
Recruiting
Phase 2

SGLT2i Improve Left Atrial Function in Patients With Paroxysmal Atrial Fibrillation, Hypertension and Abnormal Glucose Metabolism

HypertensionAtrial Fibrillation (AF)
Huashan Hospital66 enrolled1 locationNCT07482020
Recruiting
Not Applicable

Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study

Atrial Fibrillation (AF)
Vektor Medical423 enrolled13 locationsNCT06935591
Recruiting
Not Applicable

Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial

Atrial Fibrillation (AF)Catheter AblationAtrial Functional Mitral Regurgitation
Beijing Anzhen Hospital146 enrolled17 locationsNCT06883864
Recruiting
Not Applicable

Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF

Atrial Fibrillation (AF)Atrioventricular BlockPacemaker Therapy+1 more
University Hospital of Patras244 enrolled1 locationNCT07250529
Recruiting
Not Applicable

Discontinuation of Anticoagulation With Intensive Rhythm Monitoring in Post-ablation Patients With Atrial Fibrillation

Atrial Fibrillation (AF)
Beijing Anzhen Hospital4,100 enrolled22 locationsNCT06871228
Recruiting
Not Applicable

WATCHMAN FLX Pro European Registry

Left Atrial Appendage ClosureNon-valvular Atrial Fibrillation (AF)
Boston Scientific Corporation1,000 enrolled3 locationsNCT07262255
Recruiting
Not Applicable

Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation

Atrial Fibrillation (AF)Diseases of the Circulatory SystemAtrial Flutter
Samsung Medical Center520 enrolled1 locationNCT07447297
Recruiting
Not Applicable

A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

Atrial Fibrillation (AF)Persistant Atrial Fibrillation
Boston Scientific Corporation699 enrolled37 locationsNCT07187115
Recruiting

Blood Pressure Monitor (TH-75) Atrial Fibrillation Detection Function Clinical Trial

Atrial Fibrillation (AF)
Andon Health Co., Ltd392 enrolled1 locationNCT07442175
Recruiting
Not Applicable

Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.

Obesity, OverweightAtrial Fibrillation (AF)
University of Eastern Finland158 enrolled4 locationsNCT07430007
Recruiting

Incidence of Long-TeRm Atrial Fibrillation After Acute Illness

Atrial Fibrillation (AF)
University of California, San Diego100 enrolled1 locationNCT07434674
Recruiting
Not Applicable

Ablation of Human Cardiac Fibrillation Based on Models of Hierarchical Organization of Tissue Excitation

Atrial Fibrillation (AF)Ablation TreatmentTerFib_Hyerarchy
Hospital San Carlos, Madrid78 enrolled1 locationNCT07390175
Recruiting
Not Applicable

Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication

Atrial Fibrillation (AF)Heart Failure With Preserved Ejection Fraction (HFpEF)Heart Failure With Mildly Reduced Ejection Fraction+2 more
Nova Scotia Health Authority84 enrolled1 locationNCT07272902
Recruiting
Phase 3

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

Atrial Fibrillation (AF)
Anthos Therapeutics, Inc.1,900 enrolled721 locationsNCT05712200
Recruiting
Not Applicable

The Southern-Norway Post-Stroke Atrial Fibrillation Study

Atrial Fibrillation (AF)Ischemic StrokeAtrial Fibrillation (Prevention of Stroke)+2 more
Sorlandet Hospital HF450 enrolled1 locationNCT07407790