Atrial Fibrillation (AF) Clinical Trials

88 recruiting

Atrial Fibrillation (AF) Trials at a Glance

90 actively recruiting trials for atrial fibrillation (af) are listed on ClinicalTrialsFinder across 6 cities in 48 countries. The largest study group is Not Applicable with 59 trials, with the heaviest enrollment activity in Beijing, Atlanta, and Boston. Lead sponsors running atrial fibrillation (af) studies include Beijing Anzhen Hospital, University of California, San Francisco, and Asklepios proresearch.

Browse atrial fibrillation (af) trials by phase

Treatments under study

About Atrial Fibrillation (AF) Clinical Trials

Looking for clinical trials for Atrial Fibrillation (AF)? There are currently 88 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Atrial Fibrillation (AF) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Atrial Fibrillation (AF) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 90 trials

Recruiting
Phase 3

Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable

Atrial Fibrillation (AF)
Regeneron Pharmaceuticals2,628 enrolled5 locationsNCT07430956
Recruiting
Phase 2

Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation

Atrial Fibrillation (AF)
Regeneron Pharmaceuticals1,200 enrolled42 locationsNCT07175428
Recruiting
Not Applicable

Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Heart FailureCardiac DiseaseAtrial Fibrillation (AF)+4 more
Abbott Medical Devices200 enrolled13 locationsNCT07217392
Recruiting
Not Applicable

Peri-procedural Hydration to Prevent Acute Kidney Injury After Pulsed Field Ablation for Atrial Fibrillation

Acute Kidney InjuryAtrial Fibrillation (AF)
Beijing Anzhen Hospital290 enrolled1 locationNCT07490808
Recruiting
Not Applicable

Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED)

Atrial Fibrillation (AF)Atrial Flutter
Ottawa Heart Institute Research Corporation190 enrolled1 locationNCT07002450
Recruiting

Association Between Early Recurrence and Long-Term Recurrence After Pulsed Field Ablation for Atrial Fibrillation: Prospective Real-World Evidence From China

Atrial Fibrillation (AF)
West China Hospital1,200 enrolled1 locationNCT07518966
Recruiting
Not Applicable

Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

Atrial Fibrillation (AF)Persistent Atrial FibrillationParoxysmal Atrial Fibrillation (PAF)
Medtronic Cardiac Ablation Solutions400 enrolled30 locationsNCT07298473
Recruiting
Not Applicable

WATCHMAN FLX Pro European Registry

Left Atrial Appendage ClosureNon-valvular Atrial Fibrillation (AF)
Boston Scientific Corporation1,000 enrolled7 locationsNCT07262255
Recruiting
Not Applicable

Remote ECG Monitoring Post TAVI

Atrial Fibrillation (AF)Remote MonitoringArrythmia+2 more
Medical University of Silesia250 enrolled4 locationsNCT07521800
Recruiting
Not Applicable

Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)

Heart FailureCancerDiabetes+4 more
Amager Hospital2,800 enrolled1 locationNCT07518446
Recruiting
Not Applicable

Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

Atrial Fibrillation (AF)Persistant Atrial FibrillationParoxysmal AF
Arga Medtech SA360 enrolled27 locationsNCT06784466
Recruiting
Not Applicable

Comparative Study on the Safety and Efficacy of Using AccuSafe Transseptal Guidewire Versus Traditional Transseptal Needle for Transseptal Puncture in non-or Free- Guidance

Atrial Fibrillation (AF)
Second Affiliated Hospital of Nanchang University80 enrolled1 locationNCT07515040
Recruiting
Phase 3

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

Atrial Fibrillation (AF)
Anthos Therapeutics, Inc.1,900 enrolled734 locationsNCT05712200
Recruiting
Not Applicable

A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

Atrial Fibrillation (AF)Persistant Atrial Fibrillation
Boston Scientific Corporation699 enrolled37 locationsNCT07187115
Recruiting

COCONUT Study Concomitant PVI and LAAC

Atrial Fibrillation (AF)
Asklepios proresearch60 enrolled1 locationNCT06861673
Recruiting

LA Function After PFA in Paroxysmal AF

Atrial Fibrillation (AF)
Charles University, Czech Republic50 enrolled1 locationNCT07439016
Recruiting
Not Applicable

Comparative Intra-procedural Evaluation of Farapulse and FARAWAVE Nav Catheters

Atrial Fibrillation (AF)Atrial Fibrillation AblationPulsed Field Ablation
Cardiocentro Ticino58 enrolled1 locationNCT07130773
Recruiting
Phase 2

SGLT2i Improve Left Atrial Function in Patients With Paroxysmal Atrial Fibrillation, Hypertension and Abnormal Glucose Metabolism

HypertensionAtrial Fibrillation (AF)
Huashan Hospital66 enrolled1 locationNCT07482020
Recruiting
Not Applicable

Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study

Atrial Fibrillation (AF)
Vektor Medical423 enrolled13 locationsNCT06935591
Recruiting
Not Applicable

Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial

Atrial Fibrillation (AF)Catheter AblationAtrial Functional Mitral Regurgitation
Beijing Anzhen Hospital146 enrolled17 locationsNCT06883864