RecruitingPhase 3NCT06634966

Segmentectomy for Solid-dominant Lung Cancer

Segmentectomy for Solid-dominant GGO-featured Invasive Lung Cancer With Size of 2-3cm: a Single-arm, Multi-center, Phase III Trial

Sponsor

Fudan University

Enrollment

277 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Lung Adenocarcinoma Segmentectomy

Summary

This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1025. The goal of this clinical trial is to confirm the theraputic effect of segmentectomy for solid-dominant invasive lung cancer with size of 2-3cm. The main questions it aims to answer are: * The 5-year disease-free survival of patients having solid-dominant invasive lung cancer with size of 2-3cm; * The post-operative lung function tests after receiving segmentectomy. Participants will receive segmentectomy as the surgical procedure.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of lung cancer surgery for people with a specific type of early-stage lung cancer. It tests whether a smaller, more limited operation (segmentectomy) is as effective as a larger one (lobectomy) for solid-dominant lung tumors between 2–3 cm in size. The goal is to preserve more healthy lung tissue while still removing the cancer effectively. **You may be eligible if...** - You are between 18 and 80 years old - You have invasive lung adenocarcinoma confirmed by biopsy or surgery - Your tumor is between 2 and 3 cm with solid component making up 50–100% of the nodule - You have not had prior lung cancer surgery or chemotherapy/radiation - Your cancer appears confined to the lung (no lymph node spread or distant spread) - Your overall physical status is excellent (ECOG 0–1) **You may NOT be eligible if...** - Your tumor does not fall within the required size or density range - The cancer cannot be completely removed - The tumor is not a lung adenocarcinoma type - You have received prior treatment for lung cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURESegmentectomy

The lungs are divided into multiple lobes. A segmentectomy involves the removal of part of one of the lobes of the lung to entirely remove a cancerous tumor. segmentectomy can preserve more normal functional lung tissues.