RecruitingEarly Phase 1NCT06636812

Losartan and Emotional Processing in Young People

The Effects of Single-dose Losartan on the Processing of Emotional Information in Healthy Adolescents: a Randomised Controlled Study


Sponsor

University of Oxford

Enrollment

60 participants

Start Date

Mar 7, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in young healthy volunteers.


Eligibility

Min Age: 16 YearsMax Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether losartan — a blood pressure medication — can change how young people emotionally process threatening or fear-related information. It is a research study in healthy young people (not a treatment trial), conducted in Oxford, UK. **You may be eligible if...** - You are a healthy young person (likely 16–30 years old, as 16–17 year olds need parental consent) - You are a non-smoker or light smoker (fewer than 5 cigarettes per day) - You can travel to Oxford for appointments - You are willing to share your GP's contact details **You may NOT be eligible if...** - You have or have ever had a significant mental health diagnosis (e.g., depression, anxiety disorder, schizophrenia) - You are taking any brain-affecting medications or blood pressure medications - You have kidney problems, very low blood pressure, or a history of epilepsy - You weigh less than 35 kg - You have a history of serious heart or blood vessel conditions - You have a first-degree family member with severe psychiatric illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLosartan potassium

Single dose losartan (25mg or 50 mg, weight-adjusted), encapsulated identically to placebo

OTHERPlacebo

Single tablet encapsulated identically to placebo


Locations(1)

Warneford Hospital, University of Oxford

Oxford, Oxfordshire, United Kingdom

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NCT06636812


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