PrEP Readiness Interventions for Sustained Motivation (PRISM)
Optimizing HIV Prevention for Highly Vulnerable Methamphetamine-using Sexual Minority Men
Florida International University
400 participants
Jan 28, 2025
INTERVENTIONAL
Conditions
Summary
This is a hybrid type I, factorial randomized controlled trial to test the comparative and combined effectiveness of contingency management (CM) alone or CM with motivational interviewing (MI) for optimizing entry or re-entry into the PrEP care continuum. A total of 400 participants will be randomized to CM (n = 200) or MI+CM (n = 200), all delivered via Telehealth. Monthly follow-up assessments will be completed over 12 months to examine differential effectiveness for the primary outcome - filling a PrEP prescription (verified using a digital photo or detectable tenofovir diphosphate). Secondary outcomes will include: self-reported PrEP clinical evaluation by a PrEP provider; self-reported meth and other substance use severity (ASSIST), and self-reported receptive and insertive condomless anal sex (CAS).
Eligibility
Inclusion Criteria4
- years or older
- Assigned male a birth
- Self-reported methamphetamine use in the past 3 months
- Has not filled a PrEP prescription in the past 6 months
Exclusion Criteria1
- Unwilling or unable to provide informed consent
Interventions
This telehealth MI intervention seeks to increase intrinsic motivation and self-efficacy for starting or restarting pre-exposure prophylaxis (PrEP) in session one. Session two focuses on concomitant risk behaviors such as substance use and CAS.
Provides incentives for initiating PrEP care ($50) and filling a PrEP prescription ($50) in the three months following randomization.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06637436