RecruitingNot ApplicableNCT06641297

White Matter Plasticity in Schizophrenia


Sponsor

University of Maryland, Baltimore

Enrollment

36 participants

Start Date

Jan 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.


Eligibility

Min Age: 15 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating changes in the brain's white matter (the communication pathways between brain regions) in people with schizophrenia or related conditions, using brain imaging and motor tasks. **You may be eligible if...** - You are between 15 and 45 years old - You have a diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or a related psychotic condition - You are able to give informed consent **You may NOT be eligible if...** - You have metal implants or claustrophobia that would prevent an MRI scan - You have a medical condition that limits the use of your hands (such as arthritis) - You have had an active substance use disorder (other than nicotine) in the past 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMusic video game

The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'


Locations(2)

Maryland Psychiatric Research Center

Catonsville, Maryland, United States

University of Maryland Baltimore - Maryland Psychiatric Research Center

Catonsville, Maryland, United States

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NCT06641297


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