Liposomal Bupivacaine and Bupivacaine for TTMPB in Median Sternotomy
Liposomal Bupivacaine and Bupivacaine Alone Transverse Thoracic Muscle Plane Blocks in Median Sternotomy: a Prospective, Single-blind, Randomized Controlled Study
Tongji Hospital
38 participants
Oct 24, 2024
INTERVENTIONAL
Conditions
Summary
In light of the ongoing controversy surrounding the efficacy of bupivacaine liposomes, our study was designed to investigate, for the first time, the differential postoperative analgesic effects between bupivacaine liposomes combined with bupivacaine hydrochloride and bupivacaine hydrochloride alone in transverse thoracic muscle plane block treatment. The aim is to provide evidence-based medical guidance for drug selection in regional block local anesthesia.
Eligibility
Inclusion Criteria3
- Patients aged 18-90 years;
- ASA Class I \~ III;
- Patients undergoing elective median sternotomy.
Exclusion Criteria11
- Emergency surgery;
- Re-operation;
- Coagulation dysfunction;
- Preoperative left ventricular function was poor (ejection fraction \<35%);
- Systemic infection or injection site infection;
- Neuromuscular diseases;
- Mental illness;
- Dependence on psychotropic drugs;
- Allergic to bupivacaine liposomes and bupivacaine;
- Patients have participated in previous trials or have been determined by a surgeon or anesthesiologist to be unsuitable for randomization;
- Failure to obtain written informed consent from the patient or his/her representative
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Interventions
Liposomal bupivacaine and bupivacaine mixture were used for transverse thoracic muscle plane block (TTMPB) in experimental group.
Bupivacaine hydrochloride was used for transverse thoracic muscle plane block (TTMPB) in active control group.
Locations(1)
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NCT06646172