Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

This study is testing a treatment that uses magnetic stimulation delivered to the spinal cord through the skin (non-invasive) to try to reduce the overexcitability of motor neurons in people with ALS (amyotrophic lateral sclerosis, also known as Lou Gehrig's disease). Overactive motor neurons are thought to contribute to disease progression. **You may be eligible if...** - You are 18–80 years old - You have been diagnosed with ALS (sporadic or familial) within the past 3 years - Your ALS is at least 'possible' or 'probable' based on established diagnostic criteria - Your breathing capacity (slow vital capacity) is at least 50% of expected - Your nerve signal strength meets minimum criteria (median CMAP ≥1.5 mV) **You may NOT be eligible if...** - You are currently using certain medications such as botulinum toxin, intrathecal baclofen, digitalis, or morphine - You are enrolled in another ALS treatment trial - Your breathing or nerve function has declined too much Talk to your doctor to see if this trial is right for you.