RecruitingNot ApplicableNCT06650995

AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure


Sponsor

Technical University of Munich

Enrollment

40 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether catheter ablation (a procedure that uses heat or cold to correct abnormal heart rhythms) combined with a supervised exercise program works better than either treatment alone for people with heart failure with preserved pumping function (HFpEF) who also have atrial fibrillation (an irregular heartbeat). **You may be eligible if...** - You have been diagnosed with heart failure with preserved ejection fraction (HFpEF) - You have symptomatic atrial fibrillation that was diagnosed within the past year and has been short-lasting (persistent, not permanent) - You are physically and mentally able to perform exercise testing **You may NOT be eligible if...** - Your atrial fibrillation is paroxysmal, long-standing, or permanent - You have unstable heart disease or a recent heart attack - You have had a prior ablation procedure - Your heart pumping function (ejection fraction) is below 50% - You have significant valve disease or pulmonary hypertension Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERExercise training

exercise intervention will consist of supervised, home-based, combined training with elements of endurance, resistance and respiratory training


Locations(1)

Department of Medicine, Division of Prevention and Sports Medicine TU Munich

Munich, Germany

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NCT06650995


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