AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure
Technical University of Munich
40 participants
Feb 1, 2026
INTERVENTIONAL
Conditions
Summary
The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.
Eligibility
Inclusion Criteria2
- Diagnosed heart failure with preserved ejection fraction
- Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion)
Exclusion Criteria8
- Paroxysmal, long-persistent or permanent atrial fibrillation
- Clinically unstable coronary artery disease or acute coronary syndrome
- Physical and/or mental inability to perform exercise testing
- Prior ablation therapy
- Precapillary pulmonary hypertension at rest
- Intracardiac shunts
- Left ventricular ejection fraction \<50%
- High-degree valve insufficiency or stenosis (greater than grade 1 at rest)
Interventions
exercise intervention will consist of supervised, home-based, combined training with elements of endurance, resistance and respiratory training
Locations(1)
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NCT06650995