RecruitingNCT06651580

Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study

Pediatric Longitudinal Cohort Study of Chronic Pancreatitis (INSPPIRE 2)

Sponsor

M.D. Anderson Cancer Center

Enrollment

1,600 participants

Start Date

Apr 1, 2021

Study Type

OBSERVATIONAL

Conditions

Chronic Pancreatitis Exocrine Pancreas Carcinoma Recurrent Acute Pancreatitis

Summary

This clinical trial collects blood, saliva, urine, or stool samples to help identify possible genetic mutations that may increase a person's chance at developing pancreatic cancer. Finding genetic markers among pediatric patients with acute recurrent pancreatitis and chronic pancreatitis may help identify patients who are at risk of pancreatic cancer.

Eligibility

Max Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood, saliva, stool, and urine samples from children who have had pancreatitis (inflammation of the pancreas) to look for genetic mutations that increase their risk of developing serious pancreatic problems — including chronic pancreatitis or even pancreatic cancer — later in life. **You may be eligible if...** - Your child is under 18 years old - Your child has had at least one episode of acute pancreatitis, recurrent pancreatitis, or chronic pancreatitis - A parent or guardian provides written informed consent - Your child provides assent (if old enough to do so) **You may NOT be eligible if...** - Your child does not meet the clinical criteria for acute, recurrent, or chronic pancreatitis - A parent or guardian is unwilling to sign consent or authorize use of protected health information Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBiospecimen Collection

Undergo collection of blood, saliva, urine or stool samples

OTHERQuality-of-Life Assessment

Complete QoL assessment

OTHERQuestionnaire Administration

Complete questionnaire

Locations(26)

Children's Hospital Los Angeles

Los Angeles, California, United States

Cedars Sinai Medical Center

Los Angeles, California, United States

UCSF Benioff Children's Hospital Oakland

Oakland, California, United States

Stanford Cancer Institute Palo Alto

Palo Alto, California, United States

University of Colorado

Denver, Colorado, United States

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, United States

Riley Hospital for Children

Indianapolis, Indiana, United States

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, United States

Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, United States

Boston Children's Hospital

Boston, Massachusetts, United States

University of Minnesota/Masonic Children's Hospital

Minneapolis, Minnesota, United States

Washington University School of Medicine

St Louis, Missouri, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Nationwide Children's Hospital

Columbus, Ohio, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, United States

University of Texas Southwestern/Children's Medical Center

Dallas, Texas, United States

M D Anderson Cancer Center

Houston, Texas, United States

Texas Children's Hospital

Houston, Texas, United States

Children's Hospital of San Antonio

San Antonio, Texas, United States

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, United States

Sydney Children's Hospital

Randwick, New South Wales, Australia

Hospital for Sick Children

Toronto, Ontario, Canada

The Montreal Children's Hospital of the MUHC

Montreal, Quebec, Canada

Hadassah University Hospital

Jerusalem, Israel

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06651580

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