A Study of LCAR-AIO in Subjects With Relapsed/Refractory Systemic Lupus Erythematosus

This study is testing a new CAR-T cell therapy called LCAR-AIO in people with relapsed or treatment-resistant lupus (systemic lupus erythematosus, or SLE) — an autoimmune disease where the immune system attacks the body's own tissues. CAR-T therapy involves re-engineering your own immune cells to calm the overactive immune response. **You may be eligible if...** - You are 18–65 years old - You have had a confirmed SLE diagnosis for at least 6 months - Blood tests show positive antibodies typical of SLE (ANA, anti-dsDNA, or anti-Sm) - Your lupus has relapsed or not responded to standard treatments - Your organ function meets required lab values **You may NOT be eligible if...** - You are under 18 or over 65 - Your lupus is in stable remission on current treatment - You have serious infections or other autoimmune diseases not related to lupus - Your organ function is too impaired Talk to your doctor to see if this trial is right for you.