RecruitingNot ApplicableNCT06654401

Electrical Cardioversion As a Predictor in Postoperative Preservation of Sinus Rhythm

Electrical Cardioversion As a Predictor in Postoperative Preservation of Sinus Rhythm in Patients with Persistent Atrial Fibrillation Before Radio Frequency Pulmonary Vein Isolation


Sponsor

Saint Petersburg State University, Russia

Enrollment

125 participants

Start Date

Nov 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this study is to evaluate benefits of electric cardioversion in the early and long-term postoperative period in patients after radiofrequency catheter isolation of pulmonary veins. Parameters of the left atrium will be evaluated by transthoracic echocardiography and electroanatomic mapping. Preservation of the sinus rhythm will be assessed by 24-hour electrocardiographic monitoring. The main question that is planned to be answered is: Does a reverse remodeling of the left atrium and/or a decrease in the progression of the fibrosis zone occur after performing electrical cardioversion (and before subsequent catheter ablation) in patients with persistent and long-standing persistent atrial fibrillation (AF)? Can performed electrical cardioversion serve as a predictor of AF freedom in this group of patients? Participants will undergo a follow-up examinations (echocardiography, ECG, 24-hour ECG monitoring) at the 3rd, 6th and 12th months after catheter ablation. Based on the results of these examinations, the recurrence rate of AF will be estimated. Two groups of patients will include both persistent and long-standing persistent AF. Experimental group will include patients who underwent electrical cardioversion before the intervention, and active comparator group will include those patients who did not undergo it. The experimental group will be subdivided into a persistent AF patients who were successfully cardioverted in sinus rhythm and persistent AF patients who failed to restore sinus rhythm during DC at the time of catheter ablation. Analysis and comparison of subgroups will be performed.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether the results of an electrical cardioversion (a procedure that uses a controlled electric shock to reset an irregular heartbeat back to normal rhythm) before surgery can predict whether a patient will maintain a normal heart rhythm after a heart operation. **You may be eligible if...** - You have persistent atrial fibrillation (irregular heartbeat that has continued for 6 months or more despite medications) - Your left atrium (upper heart chamber) is not excessively enlarged (under 55 mm, volume under 130 ml) - You are scheduled for cardiac surgery - You have signed informed consent **You may NOT be eligible if...** - Your atrial fibrillation has a reversible cause (e.g., overactive thyroid, pericarditis) - Your left atrium is severely enlarged - You have certain other heart conditions or clotting issues that make cardioversion unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTTransthoracic echocardiography

Standard assessment of the parameters of the left atrium: size, volume, volume indices

DIAGNOSTIC_TEST24-hour ECG Monitor

Assessment of cardiac arrhythmias according to 24-hour monitoring data

PROCEDUREElectroanatomic mapping

Intraoperative assessment of low voltage areas (potential fibrosis zones)


Locations(1)

Saint Petersburg State University Clinic

Saint Petersburg, Sankt-Peterburg, Russia

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NCT06654401


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