A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case

This study is testing schema therapy — a type of psychotherapy that addresses deep-rooted thought and behavior patterns — in patients with difficult-to-treat or long-standing depression that has not responded to antidepressants or other treatments. **You may be eligible if...** - You have been referred to a psychiatric clinic for depression as your primary diagnosis - You have chronic major depression (lasting at least 2 years) OR treatment-resistant depression (failed at least 2 antidepressant trials) - You are willing to engage in an intensive therapy process **You may NOT be eligible if...** - Your primary diagnosis is something other than depression - Your depression has responded well to standard treatment - You have conditions that would interfere with psychotherapy participation (e.g., active psychosis) - You are unable to commit to the therapy schedule Talk to your doctor to see if this trial is right for you.