RecruitingPhase 4NCT06666621

Endogenous Opioid Response to Injections

Antagonism of Endogenous Opioids: Use in Interpretation of Injections

Sponsor

Middle Tennessee Research Institute

Enrollment

33 participants

Start Date

Aug 22, 2024

Study Type

INTERVENTIONAL

Conditions

Low Back Pain Zygapophyseal Joint Arthritis

Summary

This study will study pain relief after spine injections that are used to guide care. Some improvements in pain from a procedure might be from placebo effect rather than the physiological effect of the procedure. The study will use naloxone to reverse the effect of the body's internal placebo system after a spine injection, so the placebo effect and the injection effect can be measured separately. This process may improve the understanding of spine injections and their ability to guide pain care.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Naloxone infusion and a drug called Normal saline infusion for people with low back pain and zygapophyseal joint arthritis. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNormal saline infusion

After assessment of response to lumbar medial branch block, 8 ml normal saline will be infused through IV over several minutes. 10 minutes will pass, and response to lumbar medial branch block procedure will be re-assessed. After this step, naloxone infusion will occur (see next intervention)

DRUGNaloxone infusion

After infusion of normal saline and re-assessment of response to lumbar medial branch block procedure, 8 milligrams of naloxone will be infused over several minutes. Then after 10 minutes, response to lumbar medial branch block procedure will be re-reassessed for the final time.