RecruitingNCT06667414

Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

Frequency of Selected Single Nucleotide Polymorphisms in Phase With the Mutant and Wild-Type HTT Alleles in Huntington Disease Gene Expansion Carriers

Sponsor

Hoffmann-La Roche

Enrollment

600 participants

Start Date

Sep 2, 2024

Study Type

OBSERVATIONAL

Conditions

Huntington Disease

Summary

For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the wild-type Huntington (wtHTT) and mutant Huntington (mHTT) alleles.

Eligibility

Min Age: 25 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a new treatment for people with huntington disease. The study is currently recruiting participants at 45 locations. People eligible for this study include aged 25 Years to 60 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(45)

Uab Medicine

Birmingham, Alabama, United States

Barrow Neurological Institute

Phoenix, Arizona, United States

University of California San Diego

La Jolla, California, United States

University of California Davis Medical System

Sacramento, California, United States

CenExel Rocky Mountain Clinical Research, LLC

Englewood, Colorado, United States

University of South Florida

Tampa, Florida, United States

Northwestern University

Chicago, Illinois, United States

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

John Hopkins University School of Medicine

Baltimore, Maryland, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

EvergreenHealth Investigational Drug Services

Kirkland, Washington, United States

Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, Argentina

Calvary Health Care Bethlehem

Caulfield South, New South Wales, Australia

Westmead Hospital

Westmead, New South Wales, Australia

Royal Melbourne Hospital

Parkville, Victoria, Australia

Graylands Hospital

Mount Claremont, Western Australia, Australia

University of Alberta

Edmonton, Alberta, Canada

University of British Columbia Hospital

Vancouver, British Columbia, Canada

Centricity Research

Halifax, Nova Scotia, Canada

North York General Hospital

Toronto, Ontario, Canada

McGill University

Montreal, Quebec, Canada

Rigshospitalet, Hukommelsesklinikken

København Ø, Denmark

Charité - Universitätsmed. Berlin, Klinik für Psychiatrie und Psychotherapie

Berlin, Germany

St. Josef-Hospital, Neurologische Klinik der Ruhr-Uni

Bochum, Germany

Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie

Erlangen, Germany

Universitätsklinikum Ulm

Ulm, Germany

Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, Lombardy, Italy

Universita Degli Studi Di Firenze

Florence, Tuscany, Italy

Auckland DHB - Neurlogy Department

Auckland, New Zealand

New Zealand Brain Research Institute

Christchurch, New Zealand

Wellington Hospital

Wellington, New Zealand

Szpital Sw. Wojciecha

Gda?sk, Poland

Wojskowy Instytut Medycyny Lotniczej

Warsaw, Poland

Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria

Lisbon, Portugal

CNS - Campus Neurológico

Torres Vedras, Portugal

Hospital Universitario de Badajoz

Badajoz, Spain

Hospital de la Santa Creu i Sant Pau

Barcelona, Spain

Hospital Universitario de Burgos. Servicio de Neurología

Burgos, Spain

Hospital Ramon y Cajal

Madrid, Spain

Birmingham and Solihull Mental Health Foundation NHS Trust

Birmingham, United Kingdom

Addenbrookes Hospital

Cambridge, United Kingdom

National Hospital For Neurology and Neurosurgery

London, United Kingdom

John Radcliffe Hospital

Oxford, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT06667414

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