Huntington Disease Clinical Trials

40 recruiting

Huntington Disease Trials at a Glance

40 actively recruiting trials for huntington disease are listed on ClinicalTrialsFinder across 6 cities in 21 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Leuven, Parkville, and Boston. Lead sponsors running huntington disease studies include Assistance Publique - Hôpitaux de Paris, Hoffmann-La Roche, and Skyhawk Therapeutics, Inc..

Browse huntington disease trials by phase

Treatments under study

About Huntington Disease Clinical Trials

Looking for clinical trials for Huntington Disease? There are currently 40 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Huntington Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Huntington Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 40 trials

Recruiting
Phase 3

A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

Huntington Disease
Novartis Pharmaceuticals770 enrolled10 locationsNCT07326709
Recruiting

Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

Huntington Disease
Hoffmann-La Roche600 enrolled45 locationsNCT06667414
Recruiting
Not Applicable

Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease

Huntington Disease
First Affiliated Hospital of Fujian Medical University24 enrolled1 locationNCT07513844
Recruiting
Phase 2Phase 3

Study of SKY-0515 for Safety, Efficacy, and Pharmacodynamics in Participants With Huntington's Disease

Huntington DiseaseHuntingtons Disease
Skyhawk Therapeutics, Inc.120 enrolled12 locationsNCT06873334
Recruiting

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

Cystic FibrosisHuntington DiseaseSickle Cell Disease+12 more
Assistance Publique - Hôpitaux de Paris550 enrolled1 locationNCT06147414
Recruiting
Phase 2Phase 3

Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease

Huntington Disease
Skyhawk Therapeutics, Inc.400 enrolled4 locationsNCT07378644
Recruiting
Phase 1Phase 2

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

Huntington Disease
Hoffmann-La Roche53 enrolled5 locationsNCT06826612
Recruiting
Phase 1Phase 2

Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease

Huntington Disease
Leslie Thompson21 enrolled1 locationNCT07451613
Recruiting
Early Phase 1

iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009

Huntington DiseasePositron Emission TomographyImaging+5 more
CHDI Foundation, Inc.27 enrolled1 locationNCT06634628
Recruiting

Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

Juvenile Huntington DiseaseJuvenile-Onset Huntington Disease
University of Iowa40 enrolled6 locationsNCT05707663
Recruiting

Evaluation of Three Tests to Assess Social Cognition in Huntington Disease

Huntington Disease
Region Skane40 enrolled1 locationNCT07253038
Recruiting

Cognitive Assessment Tools for Huntington's Disease.

Huntington Disease
Ohio State University76 enrolled1 locationNCT06546488
Recruiting
Not Applicable

Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease

Huntington Disease
University Hospital, Montpellier135 enrolled1 locationNCT04012411
Recruiting
Not Applicable

Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease

Huntington Disease
The University of Texas Health Science Center at San Antonio16 enrolled1 locationNCT06843252
Recruiting
Not Applicable

Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

Huntington Disease
The University of Texas Health Science Center, Houston10 enrolled1 locationNCT05326451
Recruiting

Hinting Task for Huntington's Disease

Huntington Disease
University Medical Center Groningen52 enrolled1 locationNCT06774443
Recruiting

Digital Measures for Clinical Trial Endpoints in Huntington's Disease

HealthyHuntington Disease
University of Rochester100 enrolled1 locationNCT07010705
Recruiting
Not Applicable

Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)

Huntington Disease
Poitiers University Hospital15 enrolled1 locationNCT06414967
Recruiting
Not Applicable

Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3)

Huntington DiseaseParkinson Disease
University of Virginia136 enrolled1 locationNCT07213648
Recruiting

Longitudinal Endpoint Assessment of Disease Burden in HD

Huntington Disease
Huntington Study Group600 enrolled1 locationNCT06475898