RecruitingPhase 2NCT06667622

Sodium Glycididazole Reduces the Adverse Reactions of Concurrent Chemoradiotherapy

Sodium Glycididazole Reduces Chemoradiotherapy-related Adverse Reactions During Concurrent Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer


Sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Enrollment

40 participants

Start Date

May 29, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

To evaluate the efficacy and toxicity of sodium glycididazole combined with concurrent chemoradiotherapy in patients with unresectable locally advanced non-small cell lung cancer after neoadjuvant chemoradiotherapy.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether adding sodium glycididazole — a drug that may help protect normal tissues from radiation damage — reduces side effects in people with unresectable (inoperable) non-small cell lung cancer who are receiving combined chemotherapy and radiation after initial treatment. **You may be eligible if...** - You have confirmed non-small cell lung cancer (NSCLC) - Your cancer is at an unresectable stage II or III after prior neoadjuvant (pre-treatment) therapy - You are in acceptable health (ECOG 0–2) with adequate organ function **You may NOT be eligible if...** - You have previously received radiation therapy - You have had prior immune-related lung inflammation (pneumonitis) of grade 2 or higher - Your cancer requires surgery - You have another primary cancer - You have a primary immune deficiency - Your cancer has mixed small cell and non-small cell features Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGsodium glycididazole

Sodium glycididazole is intravenously infused at a dose of 800mg at 60 min before radiotherapy and used on Mondays, Wednesdays and Fridays during radiotherapy.


Locations(1)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

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NCT06667622


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