Use Misoprostol to Optimize Prevention of Cervical Cancer

This study tests whether using misoprostol (a medication that softens the cervix) can improve the success of a cervical cancer prevention procedure called LEEP or cold knife conization. These procedures remove pre-cancerous cells from the cervix, and the study focuses on women with a specific cervical anatomy (Type 3 transformation zone) that makes the procedure more difficult. **You may be eligible if...** - You are 25 or older - You have a Type 3 transformation zone confirmed by exam (meaning the cervix's cell-change zone extends inside the cervical canal, making it harder to assess) **You may NOT be eligible if...** - You have a Type 1 or Type 2 transformation zone - You are pregnant - You have had a hysterectomy - You have a cancerous lesion - You have active cervical infection Talk to your doctor to see if this trial is right for you.